Quadriceps muscle fat infiltration is associated with cardiometabolic risk in COPD

Clinical Physiology and Functional Imaging
Isabelle VivodtzevJean-Louis Pépin

Abstract

Losses of peripheral muscle mass and ectopic fat accumulation have been associated with cardiometabolic morbidity in COPD. We aimed at identifying the relationship between quadriceps muscle fat infiltration and cardiovascular risk. From 2009 to 2014, 78 COPD patients (64 ± 8 years; 80% male) were prospectively included after having given written consent (ethical committee approval number: 2006-A00491-50). The cohort was divided into three groups (tertiles) according to body mass index (BMI), low [15 < BMI≤23·3], middle [23·3 < BMI≤27·6] and high [27·6 < BMI≤36] kg/m²). Measurements were respiratory function, plasmatic biomarkers and surrogate markers of cardiovascular risk (arterial stiffness and endothelial function). Mid-thigh quadriceps muscle volume and per cent of muscle fat infiltration, as assessed by 64-slice CT scanning, were compared between the tertiles. ANOVA or Kruskal-Wallis tests were used for statistical analyses with Bonferroni's correction for the 'post hoc' tests. Intramuscular fat volume was 52% [95% CI, 43 to 60%] of total quadriceps volume in high BMI vs. 47% [38 to 55%] and 34% [29 to 38%] in the middle and low-BMI groups, respectively (P<0·0001), without differences between groups in fat-free muscle volu...Continue Reading

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Citations

Nov 28, 2020·Journal of Cachexia, Sarcopenia and Muscle·Ziye XuTizhong Shan
Oct 30, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Marina HlavatiSilva Butković-Soldo
Mar 15, 2021·Aging Clinical and Experimental Research·Praval KhanalChristopher I Morse
Feb 3, 2022·Journal of Cachexia, Sarcopenia and Muscle·Chun-Wei LiGao-Shan Liu

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