Quadruplex knots as network nodes: nano-partitioning of guanosine derivates in supramolecular hydrogels

Soft Matter
Giovanni NavaPaolo Mariani

Abstract

Aqueous solutions of guanosine-5'-monophosphates (GMP) - known to form G-quadruplexes and liquid crystal phases - can be induced to turn into high water content gels by the addition of guanosine (Gua). By a combination of Light Scattering (LS) and AFM we show that Gua/GMP hydrogels are microscopically heterogeneous, formed by Gua-rich disordered microcoils of intertwined filaments ("knots") connected by GMP-rich long linear threads. The different thermal stability of knots and threads controls the gel transition.

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Citations

Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Juliana S YonedaRosangela Itri
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andreas HankeStephen D Levene

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Methods Mentioned

BETA
dynamic
Atomic Force Microscopy
AFM

Software Mentioned

LS

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