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Quake: quality-aware detection and correction of sequencing errors

Genome Biology

Dec 1, 2010

David R KelleySteven L Salzberg

Abstract

We introduce Quake, a program to detect and correct errors in DNA sequencing reads. Using a maximum likelihood approach incorporating quality values and nucleotide specific miscall rates, Quake achieves the highest accuracy on realistically simulated reads. We further demonstrate substa...read more

Mentioned in this Paper

Guanine
Severe Acute Respiratory Syndrome
Repetitive Region
M15 protein
Alkalescens-Dispar Group
Heuristics
Genome
Likelihood Functions
Beta vulgaris
AP5Z1 gene
5
631
Paper Details
References
  • References43
  • Citations196
12345
  • References43
  • Citations196
12345...

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Quake: quality-aware detection and correction of sequencing errors

Genome Biology

Dec 1, 2010

David R KelleySteven L Salzberg

PMID: 21114842

DOI: 10.1186/gb-2010-11-11-r116

Abstract

We introduce Quake, a program to detect and correct errors in DNA sequencing reads. Using a maximum likelihood approach incorporating quality values and nucleotide specific miscall rates, Quake achieves the highest accuracy on realistically simulated reads. We further demonstrate substa...read more

Mentioned in this Paper

Guanine
Severe Acute Respiratory Syndrome
Repetitive Region
M15 protein
Alkalescens-Dispar Group
Heuristics
Genome
Likelihood Functions
Beta vulgaris
AP5Z1 gene
5
631

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Related Papers

Proceedings of the National Academy of Sciences of the United States of America

High-quality draft assemblies of mammalian genomes from massively parallel sequence data

Proceedings of the National Academy of Sciences of the United States of AmericaDecember 29, 2010
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Genome Research

ABySS: a parallel assembler for short read sequence data

Genome ResearchMarch 3, 2009
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Paper Details
References
  • References43
  • Citations196
12345
  • References43
  • Citations196
12345...

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