PMID: 7031672Nov 1, 1981Paper

Qualitative abnormalities in insulin binding in a patient with extreme insulin resistance: decreased sensitivity to alterations in temperature and pH

Proceedings of the National Academy of Sciences of the United States of America
S I TaylorM J Elders

Abstract

Cultured lymphocytes transformed by Epstein--Barr virus were employed to study insulin receptors from a patient with extreme insulin resistance associated with the syndrome of leprechaunism. With cultured lymphocytes from normal subjects, insulin binding to its receptor is exquisitely sensitive to changes in temperature and pH. In cells from normal subjects, insulin binding was increased by approximately 250% as the temperature was decreased from 37 degrees C to 12 degrees C. In contrast, with cells from the leprechaun, insulin binding was only approximately 30% higher at 12 degrees C than at 37 degrees C. Similarly, insulin binding to cells from the leprechaun was markedly less sensitive to changes in pH, as compared to cells from normal subjects. Binding studies suggested that the number of insulin receptors per cell was within the normal range in this patient. Despite the unusual characteristics of insulin binding in cells from this insulin-resistant patient, the receptors were typical in at least two respects: (i) binding was inhibited normally by antibodies to the receptor; and (ii) the specificity for insulin analogs was normal (chicken insulin greater than porcine insulin much greater than guinea pig insulin greater than...Continue Reading

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Citations

Jan 1, 1983·Human Genetics·H W Rüdiger, M Dreyer
Feb 1, 1983·Journal of the Neurological Sciences·L LamG J Tevaarwerk
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·L MosthafA Ullrich
Apr 1, 1994·Acta Paediatrica. Supplement·S I TaylorE Wertheimer
Jun 1, 1993·Journal of Medical Genetics·L I al-GazaliK Devadas
Jun 1, 1983·The Journal of Clinical Investigation·S I Taylor, S Leventhal
Dec 1, 1985·The Journal of Clinical Investigation·J A HedoS I Taylor
Jul 1, 1990·The Journal of Clinical Investigation·T KadowakiS I Taylor
Jan 1, 1996·The Journal of Clinical Investigation·A BrunettiI D Goldfine
Dec 1, 1992·Journal of Endocrinological Investigation·D AcciliS I Taylor
Feb 9, 1994·Molecular and Cellular Biochemistry·E J AiyathuraiB S Moonga
Oct 12, 2012·Cellular and Molecular Life Sciences : CMLS·Latha RamalingamDebbie C Thurmond
Dec 31, 1985·Biochemical and Biophysical Research Communications·A McElduffG Grunberger
Oct 1, 1986·Metabolism: Clinical and Experimental·Y TakataA Fujinami
Jan 1, 1985·Clinics in Dermatology·C J Witkop
Jan 1, 1985·Diabetes/metabolism Reviews·S I Taylor
Jun 1, 1982·The Journal of Pediatrics·J A WidnessR Schwartz
Mar 1, 1983·Clinics in Endocrinology and Metabolism·G GrunbergerP Gorden
Nov 18, 2017·Paediatric Anaesthesia·Alana KirkwoodLouise Harding
Dec 1, 1992·American Journal of Medical Genetics·E SeemanováM Dreyer
Apr 23, 1999·Journal of Basic and Clinical Physiology and Pharmacology·S I Taylor, E Arioglu
Jul 24, 2015·Molecular Systems Biology·Isabel Xiaorong WangVivian G Cheung
Nov 1, 1986·The American Journal of Physiology·M ShimizuR A Roth
Mar 1, 1984·The Journal of Pediatrics·S A Kaplan

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