Qualitative and quantitative aspects of the serological diagnosis of early syphilis

International Journal of STD & AIDS
A McMillan, H Young

Abstract

The aim of the present study was to evaluate the use of various serological tests in the diagnosis of early syphilis. The Murex enzyme immunoassay (EIA) test was used for screening; the Venereal Diseases Research Laboratory (VDRL) test, the Treponema pallidum particle agglutination assay (TPPA) and the Mercia antitreponemal IgM EIA were used in all the patients with a positive screening test and in those with suspected syphilis or in known contacts. In 89 cases of primary syphilis, the Murex EIA screening test was positive in 67 (75%) patients, the Mercia IgM EIA in 80 (90%) cases, the VDRL in 60 (67%) cases and the TPPA in 85 (96%) cases. All the tests were positive in 68 patients with secondary syphilis. In 72 cases of early latent syphilis, the Murex EIA screening test was positive in 68 (94%) patients, the Mercia IgM EIA in 50 (69%) cases, the VDRL in 61 (85%) cases and the TPPA in 68 (94%) cases. The Mercia IgM EIA was the only test positive in four (6%) of these cases; these four patients were known contacts. Antibody titres in the VDRL and TPPA increased as the infection progressed.

References

Apr 20, 1968·The Medical Journal of Australia·M F Garner
May 1, 1971·Southern Medical Journal·R D WendeW R Holder
Feb 1, 1983·The British Journal of Venereal Diseases·S KobayashiT Matuhasi
Apr 6, 2001·Sexually Transmitted Diseases·A M RompaloUNKNOWN Syphilis and HIV Study Group
Dec 10, 2003·Sexually Transmitted Infections·H M PalmerM A Kingston
Oct 2, 2004·Sexually Transmitted Infections·H L WheelerB T Goh
Oct 26, 2006·International Journal of STD & AIDS·K ManaviA McMillan

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Citations

Jul 23, 2014·Current Infectious Disease Reports·Karoll J Cortez, Melissa A Greenwald
May 1, 2010·BMC Infectious Diseases·Irena JakopanecPreben Aavitsland
Jul 8, 2011·The American Journal of Tropical Medicine and Hygiene·Oriol MitjàQuique Bassat
Aug 10, 2015·Sexual Health·Phillip J ReadBasil Donovan
Nov 19, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Hua ShiYongmei Jiang
Sep 4, 2009·The Korean journal of laboratory medicine·Yeong Sic KimSoo-Young Kim
Jun 25, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Susan TuddenhamKhalil G Ghanem

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Methods Mentioned

BETA
ICE
PCR

Software Mentioned

Statgraphics®

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