Qualitative and quantitative changes in the ultrastructure of the dog heart after temporary ischaemia and coronary reperfusion

Experimentelle Pathologie
H DavidH Warnke


A total ischaemia of one area of the myocardium was produced by ligature of a coronary artery in dogs. After 30 min, 1 hr, 2 hrs, and 4 hrs the ligature was loosened and the artery was for 1--2 hrs reperfused up to 4--7 days. At the end of the ischaemia and after reperfusion the ultrastructure of the myocardium was qualitatively and morphometrically investigated. The findings concerned: loss of glycogen (partly glycogen accumulation), mitochondrial swellings and fusions and development of megamitochondria, loss of cristae, rupture of the mitochondrial outer membranes, relaxation or supercontraction of the myofibrils, vesicular and vacuolar changes of the sarcoplasmic reticulum, oedema of the sarcoplasm, rupture of the sarcolemma. No significant differences of the quantitative parameters could be observed during the ischaemia from 30 min to 4 hrs: myofibrils 53.65--59.74%, mitochondria 26.51--33.59%, sarcoplasm 8.22--11.86%, sarcoplasmic reticulum 1.41--2.63%, lipofuscin 0.05--0.87%, lipids 0.01--0.10%. In comparing the data of the single animals we could determine significant differences between some parameters at the ends of the ischaemic phase and of the reperfusion phase, but as far as the findings are concerned both increas...Continue Reading


Sep 1, 1976·Beiträge Zur Pathologie·B F TrumpW J Mergner
Nov 1, 1975·Journal of Molecular and Cellular Cardiology·K SakaiH J Bretschneider
Jan 1, 1971·Cardiology·V J Ferrans, W C Roberts
Aug 1, 1972·Journal of Molecular and Cellular Cardiology·J S PartinJ C Partin
Oct 1, 1972·The American Journal of Cardiology·M A Ricciutti


Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·P K KirchnerJ Schaper
Dec 8, 2015·Analytical Chemistry·Cyril MuehlethalerJohn R Lombardi

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