PMID: 11317072Apr 24, 2001Paper

Qualitative and quantitative PCR measures of cytomegalovirus in patients with advanced HIV infection who require transfusions

Journal of Acquired Immune Deficiency Syndromes : JAIDS
M F ParaViral Activation Transfusion Study (VATS) Group

Abstract

The Viral Activation Transfusion Study (VATS) was a randomized trial that compared leukocyte-reduced transfusions with unfiltered red blood cell transfusions in HIV and cytomegalovirus (CMV) antibody-positive patients with anemia who were undergoing their first blood transfusion. The relations of the baseline qualitative and quantitative polymerase chain reaction (PCR) measures of plasma CMV viremia, HIV RNA, CD4(+) cell counts, and quality of life in these study subjects were examined. The 511 study subjects had a median CD4(+) cell count equal to 15 cells/mm3, and 110 (21.5%) had CMV viremia by qualitative assay. In multivariate models, frequency of positive qualitative CMV increased with decreasing CD4(+) cell counts (p =.04 trend), higher HIV RNA (p <.001), and a history of CMV disease (p <.001). Quantitative CMV PCR were performed on the 110 qualitative assay-positive study subjects. Median CMV viral load was 1780 copies/ml. In multivariate regression models, lower CD4(+) cell count (p =.03), and a history of CMV disease (p <.001) correlated with the level of CMV load. HIV RNA load and CMV load were not correlated. A lower Karnofsky score was associated with both the presence and quantity of CMV DNA.

Associated Clinical Trials

References

Mar 1, 1995·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·S A BozzetteA W Wu
Sep 18, 1997·The Journal of Infectious Diseases·L MoleM Holodniy
Aug 1, 1997·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·K W SmithL Swislow
Jan 24, 1998·Cytometry·E W FiebigM P Busch
Feb 7, 1998·The Journal of Clinical Investigation·S A SpectorM J Stempien
Oct 13, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·J L CasadoA Guerrero

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