Qualitative aspects of exertional breathlessness in chronic airflow limitation: pathophysiologic mechanisms

American Journal of Respiratory and Critical Care Medicine
Denis E O'DonnellKatherine A Webb

Abstract

We compared qualitative aspects of the sensory experience of exertional breathlessness in normal subjects and in patients with chronic airflow limitation (CAL) and sought a physiologic rationale for these. Twelve patients (66 +/- 2 yr of age, mean +/- SEM) with severe CAL (FEV1 = 37 +/- 5% predicted) and 12 age-matched normal subjects (FEV1 = 103 +/- 5% predicted) were studied. Perceived inspiratory difficulty (BorgIN), inspiratory effort (esophageal pressure expressed as a fraction of maximal esophageal pressure at isovolume [Pes/PImax]), breathing pattern, and operational lung volumes (end-expiratory/inspiratory lung volumes [EELV/EILV]) were measured during symptom-limited incremental cycle exercise testing and compared at a standard VO2 of 50% predicted maximum in normal subjects and in patients with CAL. Qualitative descriptors of breathlessness were selected immediately after exercise. Breathlessness was qualitatively different between normal subjects and patients with CAL. Both normal subjects and patients with CAL chose descriptors of increased "work/effort" and "heaviness" of breathing; however, only patients with CAL consistently chose descriptors denoting "increased inspiratory difficulty" (75%), "unsatisfied inspira...Continue Reading

Citations

Jul 26, 2005·Der Internist·U Wagner, C Vogelmeier
Mar 4, 2009·European Journal of Applied Physiology·Dennis JensenDenis E O'Donnell
Mar 13, 2002·Journal of Pain and Symptom Management·Andrew WilcockAnne E Tattersfield
Feb 24, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Chikako MotomuraSankei Nishima
Nov 21, 2009·Current Opinion in Pulmonary Medicine·Josuel OraDenis E O'Donnell
Apr 21, 2012·Current Opinion in Supportive and Palliative Care·Graeme J KoelwynNeil D Eves
Oct 30, 2012·Fiziologiia cheloveka·O V GrishinD Iu Uriumtsev
Mar 28, 2006·Thorax·D E O'Donnell, C M Parker
Aug 7, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·M V SzabariB Suki
May 7, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Markus AmannJerome A Dempsey
Apr 11, 2009·Journal of Applied Physiology·Stephen H LoringAtul Malhotra
Dec 6, 2012·Pulmonary Medicine·Michael K SticklandMohit Bhutani
Jan 22, 2010·Respiration; International Review of Thoracic Diseases·Roberto BianchiGiorgio Scano
Mar 24, 2012·Respiration; International Review of Thoracic Diseases·Julia L KellyNicholas S Hopkinson
Oct 6, 1997·American Journal of Respiratory and Critical Care Medicine·S YanP Sliwinski
Feb 26, 1998·American Journal of Respiratory and Critical Care Medicine·F LaghiM J Tobin
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·P J PooleP N Black
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·D E O'DonnellK A Webb
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine
Mar 2, 1999·American Journal of Respiratory and Critical Care Medicine·R C Chen, S Yan
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·J L LarsonL Edwards
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·D E O'DonnellK A Webb
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·D E O'DonnellK A Webb
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·U HatipoğluM J Tobin
Jul 21, 2000·American Journal of Respiratory and Critical Care Medicine·C TaubeH Magnussen
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·M L MoyR M Schwartzstein
Dec 9, 2000·American Journal of Respiratory and Critical Care Medicine·M HayotC Prefaut
Sep 11, 2001·American Journal of Respiratory and Critical Care Medicine·D E O'DonnellK A Webb
Jan 14, 2003·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN American College of Chest Physicians
Sep 23, 2003·American Journal of Respiratory and Critical Care Medicine·Russell S RichardsonPeter D Wagner
Mar 22, 2005·American Journal of Respiratory and Critical Care Medicine·Thierry TroostersMarc Decramer
Sep 17, 2005·American Journal of Respiratory and Critical Care Medicine·Nicola J StevensonPeter M A Calverley
Jun 9, 2006·American Journal of Respiratory and Critical Care Medicine·Linda NiciUNKNOWN ATS/ERS Pulmonary Rehabilitation Writing Committee
Mar 29, 2008·American Journal of Respiratory and Critical Care Medicine·Robert B BanzettRobert W Lansing
Jul 23, 2011·American Journal of Respiratory and Critical Care Medicine·Robert B BanzettRichard M Schwartzstein
Sep 3, 2011·American Journal of Respiratory and Critical Care Medicine·Pierantonio LavenezianaDenis E O'Donnell
Feb 18, 2012·American Journal of Respiratory and Critical Care Medicine·Mark B ParshallUNKNOWN American Thoracic Society Committee on Dyspnea
Apr 18, 2013·American Journal of Respiratory and Critical Care Medicine·Roberto C ChinDenis E O'Donnell
Jun 9, 2007·American Journal of Respiratory Cell and Molecular Biology·Zhengdong WangRobert H Notter
Jan 1, 2010·Multidisciplinary Respiratory Medicine·Francesco Gigliotti
Jan 1, 2010·Multidisciplinary Respiratory Medicine·Ernesto Crisafulli, Enrico M Clini
Nov 30, 2007·International Journal of Chronic Obstructive Pulmonary Disease·Nicolino Ambrosino, Guido Vagheggini
Nov 30, 2007·International Journal of Chronic Obstructive Pulmonary Disease·Luis Puente-Maestu, William W Stringer

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.

Related Papers

American Journal of Respiratory and Critical Care Medicine
Denis E O'DonnellK A Webb
American Journal of Respiratory and Critical Care Medicine
Donald A MahlerRichard M Schwartzstein
American Journal of Respiratory and Critical Care Medicine
Denis E O'DonnellKatherine A Webb
© 2022 Meta ULC. All rights reserved