Qualitative changes in enteric flora and short-chain fatty acids after intestinal resection

Digestive Diseases and Sciences
J S ThompsonT E Adrian

Abstract

Our aim was to determine the effect of intestinal transection and resection on the prevalence of enteric flora and evaluate whether any such changes alter luminal SCFA and lactic acid content. Dogs underwent either 50% proximal (PR, N = 6) or distal (DR, N = 7) resection, distal resection with bypass of the ileocecal junction (DRBP, N = 9) or midpoint transection alone performed to serve as the appropriate control for luminal sampling for either proximal (PTC, N = 6) or distal (DTC, N = 7) resection. Studies were performed every four weeks for 12 weeks. Both jejunum and ileum had >10(5)/ml aerobic bacteria, most commonly E. coli. Streptococcal species were more common in the normal jejunum than ileum but were found in the ileal remnant after PR. Significant (>10(5)) anaerobic growth occurred infrequently in the jejunum, and DR did not increase anaerobic growth in jejunum unless DRBP was performed (93% vs 62% DR, 45% DTC, 20% normal jejunum, P < 0.05). Clostridium species increased significantly in the jejunal remnant after DRBP. Significant anaerobic growth occurred infrequently in normal ileum but increased after PR (89% vs 50% PTC, P < 0.05). Flora normally found in the jejunum tended to increase in the ileum after PR. Jejuna...Continue Reading

Citations

Aug 12, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E M Quigley, J S Thompson
May 21, 2003·American Journal of Veterinary Research·Randal K Buddington
May 24, 2011·Journal of Neurogastroenterology and Motility·Eamonn M M Quigley
Jul 6, 2007·The Journal of Veterinary Medical Science·Yumiko ShimoyamaHiroyuki Taniyama
Nov 16, 2010·Journal of Animal Science·J S Suchodolski
Sep 17, 2005·Animal Health Research Reviews·G M NavaM P Castañeda

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