PMID: 9661966Jul 14, 1998Paper

Qualitative changes of anticonvulsant action of felbamate during development in rats

Brain & Development
R HaugvicováP Mares

Abstract

The anticonvulsant action of felbamate (25, 50, 100 and 150 mg/kg i.p.) was tested against motor seizures induced by pentylenetetrazol in five age-groups of rats (7, 12, 18, 25 and 90 days old). In adult rats, felbamate suppressed generalized tonic-clonic seizures leaving intact minimal clonic seizures. In all groups of rat pups felbamate exhibited a specific action against the tonic phase of generalized tonic-clonic seizures. In addition, the highest dose of felbamate was found to suppress minimal seizures in 18-day-old rats. The changes of felbamate action during ontogeny might be due to multiple mechanisms of anticonvulsant action with an uneven developmental profile.

References

Sep 1, 1992·Epilepsia·V E AdusumalliR D Sofia
Nov 1, 1992·Naunyn-Schmiedeberg's Archives of Pharmacology·L VelisekR Schickerova
Oct 1, 1992·Epilepsy Research·L StankováP Mares
Feb 1, 1989·Pharmacology, Biochemistry, and Behavior·L VelísekP Mares
Sep 1, 1987·Epilepsy Research·M Pohl, P Mares
Jan 7, 1993·The New England Journal of Medicine·UNKNOWN Felbamate Study Group in Lennox-Gastaut Syndrome
Jan 1, 1995·Epilepsia·R L Macdonald, K M Kelly
May 13, 1998·Epilepsia·J M Pellock, M J Brodie

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