PMID: 11902972Mar 21, 2002Paper

Qualitative determination of specific protein glycation products by matrix-assisted laser desorption/ionization mass spectrometry Peptide mapping

Journal of Agricultural and Food Chemistry
Andreas HumenyMonika Pischetsrieder

Abstract

The nonenzymatic reaction between reducing sugars and proteins, known as the Maillard reaction, has received increased recognition from nutritional science and medical research. The development of new analytical techniques for the detection of protein-bound Maillard products is therefore crucial. In this study, we applied peptide mapping by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to investigate the formation of structurally specific Maillard products on glycated lysozyme (AGE-lysozyme), produced upon incubation with D-glucose. In parallel, we synthesized N(epsilon)-(carboxymethyl)lysine-modified lysozyme (CML-lysozyme) and N(epsilon)-(carboxyethyl)lysine-modified lysozyme, two well-described glycation products, as model substances. 3-Deoxyglucosone-modified lysozyme and methylglyoxal-modified lysozyme were prepared as examples of glycation products incubated with dicarbonyl compounds. We were able to detect specific modifications on AGE-lysozyme, which were assigned to CML, imidazolone A, and the Amadori product.

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Citations

Mar 15, 2011·Journal of Agricultural and Food Chemistry·Roman BuckowYacine Hemar
Apr 15, 2011·Critical Reviews in Food Science and Nutrition·Christine M Oliver
Jan 27, 2005·Photomedicine and Laser Surgery
May 19, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Xiaohong ZhangMonika Pischetsrieder
Feb 27, 2007·European Journal of Pharmacology·Muhammad Saeed AhmadNessar Ahmed
Jul 23, 2005·Annals of the New York Academy of Sciences·Thomas KislingerMonika Pischetsrieder
Nov 5, 2005·Molecular Nutrition & Food Research·Harshadrai M RawelFlorian J Schweigert
Mar 10, 2006·Mass Spectrometry Reviews·Toshimitsu Niwa
Apr 21, 2006·Mass Spectrometry Reviews·Annunziata LapollaPietro Traldi
May 2, 2008·Annals of the New York Academy of Sciences·Jasmin Meltretter, Monika Pischetsrieder
Sep 8, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hao Jing, David D Kitts
Sep 17, 2005·Biochimica Et Biophysica Acta·M Abul FarahYangsun Kim
Sep 1, 2011·Food Chemistry·N SchneiderM Pischetsrieder
Dec 17, 2009·Diabetes·Markus A QueisserKlaus T Preissner
Oct 21, 2016·Physical Chemistry Chemical Physics : PCCP·Coralie PasquierStéphane Pezennec
Jul 19, 2002·Journal of Mass Spectrometry : JMS
Dec 13, 2017·International Journal of Molecular Sciences·Alena SobolevaAndrej Frolov
Jun 10, 2008·Journal of Agricultural and Food Chemistry·Jasmin MeltretterMonika Pischetsrieder
Apr 29, 2003·Journal of Proteome Research·Urban A KiernanRandall W Nelson
May 16, 2018·Journal of Agricultural and Food Chemistry·Lijun YangQiang Dong
Dec 22, 2005·Journal of Agricultural and Food Chemistry·Yuanxia SunKen Izumori
May 27, 2004·Journal of Agricultural and Food Chemistry·Hao Jing, David D Kitts
Jun 26, 2007·Journal of Agricultural and Food Chemistry·Jasmin MeltretterMonika Pischetsrieder

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