Qualitative difference in follicle-stimulating hormone activity in the pituitaries of young women compared to that of men and elderly women

The Journal of Clinical Endocrinology and Metabolism
L Wide, B M Hobson

Abstract

The possible existence of qualitative differences between FSH in pituitaries from men and women of different ages was investigated with the use of an in vitro bioassay, an in vitro bioassay, and a RIA. Aqueous extracts were made from pituitaries obtained at autopsy and frozen until extracted. The FSH activities per pituitary and the ratios of FSH activities as obtained with the three assay methods were similar for young and elderly men. The ratios of in vivo biological to in vitro biological FSH activities were similar for men and postmenopausal women and significantly higher than the corresponding ratio for FSH from young women. With the in vivo bioassay the activity in the extracts of pituitaries from men and young women were similar, whereas extracts from postmenopausal women had significantly higher activity. With the in vitro bioassay the extracts from young women and elderly women had a similar content of FSH activity, whereas the FSH level in the extracts of male pituitaries was significantly lower. The results of the RIA correlated well with those of the in vitro bioassay. In conclusion, the results show that FSH in pituitaries from young women has a biological activity that is qualitatively different from FSH of men an...Continue Reading

Citations

May 1, 1995·Experimental Gerontology·W G Rossmanith
Sep 1, 1991·Clinical Endocrinology·A TsatsoulisW R Robertson
Apr 10, 2007·Animal Reproduction Science·G J MacdonaldJ J Ford
Mar 14, 2007·Molecular and Cellular Endocrinology·K ReisingerM Zygmunt
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Dec 1, 1991·Journal of Endocrinological Investigation·M Simoni, E Nieschlag
Feb 15, 2019·Frontiers in Endocrinology·Stella CampoSusana B Rulli
May 28, 2019·Endocrinology·George R Bousfield, David J Harvey
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Jun 1, 1992·Aging : Clinical and Experimental Research·D Cocchi
Jul 10, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·M P Rose

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