PMID: 9358738Nov 14, 1997

Qualitative modeling of mechanoelectrical feedback in a ventricular cell

Bulletin of Mathematical Biology
Z KnudsenJ Brindley

Abstract

Mechanical changes in the heart muscle can influence its electrical properties through a process called mechanoelectrical feedback (MEF). This feedback can operate via changes in calcium dynamics during the cross-bridge cycle or via mechanosensitive (stretch-activated) channels. We present a four-variable ordinary differential equation (ODE) system that caricatures the electrical and mechanical activity of a ventricular cell and their mutual interactions. A three-variable excitable system with restitution properties of the FitzHugh-Nagumo type is coupled to a fourth equation which describes changes in cell length during a lightly loaded contraction. The resulting four-variable system models MEF in a cell and can be incorporated into spatially distributed models for mechanoelectric behavior during wave propagation in the cardiac tissue.

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Citations

Mar 10, 1999·Progress in Biophysics and Molecular Biology·M J Lab
Mar 10, 1999·Progress in Biophysics and Molecular Biology·P KohlD Noble
Jun 9, 2009·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Ken C L WongPengcheng Shi
Dec 22, 2019·Bioengineering·Eun-Jin Kim, Massimo Capoccia

Related Concepts

Kinematics
Electrophysiology (Science)
Feedback - System Communication
Heart
Mathematics

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