PMID: 6407097May 1, 1983Paper

Qualitative platelet defect in a case of heparin-induced thrombocytopenia

Scandinavian Journal of Haematology
B H ChongP A Castaldi

Abstract

A qualitative platelet defect was demonstrated in a patient with heparin-induced thrombocytopenia. His platelets showed impaired aggregation to collagen and arachidonate and absent second wave aggregation to adenosine diphosphate and epinephrine but normal response to ristocetin. These aggregation abnormalities were similar to those reported in idiopathic thrombocytopenia and systemic lupus erythematosus. This platelet function defect may contribute to haemorrhagic complications which appear to be common in heparin-induced thrombocytopenia.

References

Mar 23, 1972·The New England Journal of Medicine·R ClancyB Firkin
Nov 1, 1980·The American Journal of Medicine·H J WeissK L Kaplan
Dec 1, 1981·British Journal of Haematology·B H ChongM C Rozenberg

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Citations

Nov 1, 1989·Stroke; a Journal of Cerebral Circulation·P S Becker, V T Miller
Jul 1, 1985·Scandinavian Journal of Haematology·B H ChongP A Castaldi

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