Qualitatively different immune response of the bumblebee host, Bombus terrestris, to infection by different genotypes of the trypanosome gut parasite, Crithidia bombi

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Seth M Barribeau, Paul Schmid-Hempel

Abstract

Insects have a complex and highly successful immune system that responds specifically to different types of parasites. Different genotypes of a parasite species can differ in infectivity and virulence; which is important for host-parasite co-evolutionary processes, such as antagonistic, fluctuating selection. Such coevolution obviously requires a genetic basis, but little is known about how hosts immunologically respond to different genotypes. The common European bumblebee Bombus terrestris is infected by the highly prevalent trypanosome gut parasite, Crithidia bombi. Here we examined expression of 26 immunological and metabolic genes in response to infection by two clones of C. bombi and compared that with exposure to injection with a bacterial challenge. Exposure to the two clones of C. bombi elicits qualitatively different immune expression responses. Interestingly, infection with one clone results in up regulation of AMP's similar to bees given the bacterial challenge, while genes related to metabolism, signalling, and other effectors were similar between the two Crithidia exposures. Bees given different challenges were distinct enough to discern using linear discriminant analyses. We also found strong correlations, both po...Continue Reading

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Citations

Feb 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Seth M BarribeauPaul Schmid-Hempel
Oct 11, 2016·Current Opinion in Insect Science·Alexander J McMenaminMichelle L Flenniken
May 11, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Monika MarxerP Schmid-Hempel
May 27, 2016·Proceedings. Biological Sciences·Kathrin Näpflin, P Schmid-Hempel
Aug 20, 2016·Journal of Evolutionary Biology·Seth M Barribeau, P Schmid-Hempel
May 23, 2014·Proceedings. Biological Sciences·Franziska S BrunnerSeth M Barribeau
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Related Concepts

Antigens, Protozoan
Apidae
Crithidia
Host-Parasite Interactions
Gene Expression
Sequence Determinations, DNA
Gastrointestinal Tract Structure
Genes
Insecta
Metabolism

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