Quality-adjusted survival: a rigorous assessment of cure after cancer during childhood and adolescence

Pediatric Blood & Cancer
Ronald D Barr, Alessandra Sala

Abstract

Survivors of cancer in childhood and adolescence, while increasing gratifyingly in number with ever more effective therapy, have a life expectancy that is compromised all-too-often in both duration and value as a result of adverse treatment-related sequelae. Accounting for this burden of morbidity and mortality is essential for a proper appreciation of cure. Adjusting estimates of survival by measures of its quality affords a means of accomodating this requirement. It can be accomplished by "weighting" the length of survival according to preference-based assessments of health-related quality of life (HRQL), which allow the calculation of quality-adjusted life years. Inclusion of measures of HRQL in clinical trials is imperative as we reach to the ultimate objective; the truly cured child restored to normal health.

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Citations

Sep 19, 2008·Journal of Pediatric Hematology/oncology·Sandra ShimodaBeatriz de Camargo
Mar 24, 2012·Journal of Pediatric Hematology/oncology·Begül Yağci-KüpeliMünevver Büyükpamukçu
May 26, 2012·BMC Research Notes·Nuša ErmanBerta Jereb
Sep 18, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Daniela AlessiFranco Merletti
Mar 25, 2008·Pediatric Blood & Cancer·Gabriele Calaminus, Ronald Barr
Jan 8, 2014·European Journal of Cancer Care·C RaeR Barr
Apr 26, 2006·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Judith GrantRonald Barr
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Jan 5, 2007·Oncology Nursing Forum·Pamela S HindsCeleste R Phillips

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