Quality and quantity of diffuse and focal white matter disease and cognitive disability of patients with multiple sclerosis

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Giuseppe BomboiFrancesca Bagnato

Abstract

Using high-field magnetic resonance imaging (MRI), we investigated the relationships between white matter (WM) lesion volume (LV), normal-appearing WM (NAWM) normalized volume, WM-lesion and NAWM magnetization transfer ratios (MTRs), brain parenchyma fraction (BPF), and cognitive impairment (CI) in multiple sclerosis (MS). Twenty-four patients and 24 healthy volunteers (age, sex, and years of education-matched) underwent a 3.0 Tesla (3T) scan and evaluation of depression, fatigue, and CI using the Minimal Assessment of Cognitive Function in MS (MACFIMS) battery. In this clinically relatively well-preserved cohort of patients (median score on the Expanded Disability Status Scale=1.5), CI was detected on Symbol Digit Modalities Test (SDMT), California Verbal Learning Test-II (CVLT-II), and Controlled Oral Word Association Test. MT data were available in 19 pairs on whom correlation analyses were performed. Associations were seen between SDMT and normalized NAWM volume (P=.034, r=.502), CVLT-II long delay and normalized NAWM volume (P=.012, r=.563), WM-LV (P=.024, r=.514), and BPF (P=.002, r=.666). The use of 3T MRI in a sample of clinically stable MS patients shows the importance of WM disease in hampering processing speed and wo...Continue Reading

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Citations

Dec 12, 2012·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Clelia PellicanoFrancesca Bagnato
Dec 24, 2013·Sleep Medicine·Christian Veauthier, Friedemann Paul
Mar 31, 2015·PloS One·Francesco PattiGioacchino Tedeschi
Dec 23, 2011·Multiple Sclerosis : Clinical and Laboratory Research·D W LangdonR H B Benedict
Jan 13, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Stephen M RaoJay Alberts
May 22, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Silvana L CostaNancy D Chiaravalloti
Sep 26, 2013·Journal of the International Neuropsychological Society : JINS·Jose M LafosseChristopher M Filley
Nov 6, 2015·Frontiers in Neuroscience·Christopher S McCarthyWendy R Kates

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