Quality assessment of Fructus Ligustri Lucidi by the simultaneous determination of six compounds and chemometric analysis

Journal of Separation Science
Weifeng YaoWei Li

Abstract

A comprehensive strategy was designed for the quality assessment of Fructus Ligustri Lucidi, a well-known and commonly used herbal medicine in clinical practice in China. First, a simple and stable method of high-performance liquid chromatography was developed for the simultaneous quantitative analysis of six compounds, namely, salidroside, nuzhenide, specnuezhenide, oleanic acid, ursolic acid, and acetyl oleanic acid in Fructus Ligustri Lucidi. The separation of analytes was conducted on a C18 column (200 mm × 4.6 mm, 5 μm) at 30°C, and the wavelength of UV detector was set at 210 nm. In quantitative analysis, all of the calibration curves showed good linear regression (R(2) > 0.9994) within the tested ranges, and the mean recoveries of three different concentrations ranged from 95.21-102.34%. The described method was applied to determine 11 batches of samples collected from different stores in China. Then multiple chemometrics analysis including hierarchical cluster analysis and principal component analysis were performed to classify samples and search significant compounds. Three notable compounds, specnuezhenide, oleanic acid, and acetyl oleanic acid, were discovered for better quality control compared with those stated in ...Continue Reading

References

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Dec 11, 2007·Canadian Journal of Physiology and Pharmacology·Dawei GaoKun Li
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Dec 1, 2010·Osong Public Health and Research Perspectives·Hyun-Kyung KimShin-Hyeong Cho

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Citations

Dec 16, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ju-Han LiuTung-Hu Tsai
Sep 6, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Beibei ChenDongwei Zhang
Nov 27, 2015·Journal of Separation Science·Zhenhua zhuJin-ao Duan

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