Quality assessment of systematic reviews of vitamin D, cognition and dementia

BJPsych Open
Fariba AghajafariIan Cameron

Abstract

There is conflicting evidence regarding the association of vitamin D with cognition performance and dementia.AimsWe aimed to summarise the evidence on the association of vitamin D with cognitive performance, dementia and Alzheimer disease through a qualitative assessment of available systematic reviews and meta-analyses. We conducted an overview of the systematic reviews of all study types with or without meta-analyses on vitamin D and either Alzheimer disease, dementia or cognitive performance up to June 2017. Eleven systematic reviews were identified, nine of which were meta-analyses with substantial heterogeneity, differing statistical methods, variable methodological quality and quality of data abstraction. A Measurement Tool to Assess Systematic Reviews checklist scores ranged from 4 to 10 out of 11, with seven reviews of 'moderate' and four of 'high' methodological quality. Out of six meta-analyses on the association between low serum concentration of 25-hydroxyvitamin D and risk of dementia, five showed a positive association. Results of meta-analyses on the association between low serum concentration of 25-hydroxyvitamin D and memory function tests showed conflicting results. This systematic evaluation of available syst...Continue Reading

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Citations

Sep 26, 2020·Brain Sciences·Mahitab FarghaliFrancesca Uberti
Oct 18, 2019·Expert Opinion on Drug Discovery·Miroslava Cuperlovic-Culf, Amanpreet Badhwar

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