Quality assurance analysis of hippocampal avoidance in a melanoma whole brain radiotherapy randomized trial shows good compliance

Radiation Oncology
Geoffrey MartinageGerald B Fogarty

Abstract

Melanoma brain metastases (MBM) often cause morbidity and mortality for stage IV melanoma patients. An ongoing randomised phase III trial (NCT01503827 - WBRT-Mel) evaluates the role of adjuvant whole brain radiotherapy (WBRT) following local treatment of MBM. Hippocampal avoidance during WBRT (HA-WBRT) has shown memory and neurocognitive function (NCF) preservation in the RTOG-0933 phase II study. This study assessed the quality assurance of HA-WBRT within the WBRT-Mel trial according to RTOG-0933 study criteria. Hippocampal avoidance was allowed in approved centres with intensity-modulated radiotherapy capability. Patients treated by HA-WBRT were not randomized within the WBRT arm. The RTOG 0933 contouring Atlas was used to contour hippocampi. In the trial co-ordinating centre, patients were treated with volumetric modulated arc therapy using complementary arcs; similar techniques were used at other sites. Dosimetric data were extracted retrospectively and analysed in accordance with RTOG 0933 study constraints criteria. Among the 215 patients accrued to the WBRT-Mel study between April 2009 and September 2017, 107 were randomized to the WBRT arm, 22 were treated by HA-WBRT in 4 centers. Eighteen patients were treated in the s...Continue Reading

References

Jul 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jill S Barnholtz-SloanRaymond E Sawaya
May 31, 2007·Technology in Cancer Research & Treatment·Samuel J WangMartin Fuss
Oct 20, 2009·International Journal of Radiation Oncology, Biology, Physics·Grant M ClarkJohn B Fiveash
Apr 16, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Vinai GondiMinesh P Mehta
Apr 14, 2011·Nature Reviews. Clinical Oncology·April F EichlerRakesh K Jain
Mar 30, 2012·The Lancet Oncology·Kim MargolinF Stephen Hodi
Apr 21, 2012·International Journal of Radiation Oncology, Biology, Physics·Vesna ProkicAnca-Ligia Grosu
May 12, 2012·International Journal of Surgical Oncology·Angela HongMichael A Izard
Jan 15, 2013·International Journal of Radiation Oncology, Biology, Physics·Vinai GondiWolfgang A Tomé
May 9, 2013·Journal of Applied Clinical Medical Physics·Alexander NevelskyAbraham Kuten
Feb 25, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Angela M HongGerald Fogarty
Oct 29, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vinai GondiMinesh P Mehta
Jan 22, 2015·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Jin ShenWolfgang A Tomé
Nov 5, 2015·International Journal of Radiation Oncology, Biology, Physics·Reza FarjamYue Cao
Dec 18, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Bing SunSantai Song
Jul 3, 2016·BMC Cancer·Gerald B FogartyJohn F Thompson
Jan 9, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Petr PospisilRadim Jancalek
Feb 27, 2017·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Shuo WangSumin Zhou
Jul 22, 2017·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Tomas KazdaRadek Lakomy
Nov 13, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ting Martin MaKristin J Redmond
Dec 6, 2017·Advances in Radiation Oncology·Catherine OkoukoniMichael D Chan

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Clinical Trials Mentioned

NCT01503827
NCT02360215
NCT02635009

Software Mentioned

Eclipse
iLQ

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