Quality-by-Design Approach for the Development of Nano-Sized Tea Tree Oil Formulation-Impregnated Biocompatible Gel with Antimicrobial Properties

Pharmaceutics
Thabata MutaSanjay Garg

Abstract

Despite the promising properties of tea tree oil (TTO) as potential therapeutics for several superficial skin conditions, certain limitations such as physical instability and skin irritation have restricted its widespread use. This study focuses on developing a rationally designed lipid-based nanoformulation (TTO-LNF) in accordance with the US Food and Drug Administration standard using a well-recognized quality-by-design (QbD) approach. Using a mixture experimental design, TTO-LNF has been optimized with 5% TTO, 10% surfactant, 5% co-surfactant, and 80% water, which showed a 14.4 ± 4.4 nm droplet size and 0.03 ± 0.01 polydispersity index (PDI). To ease the topical administration, the TTO-LNF gel formulation was further developed using xanthan gum to achieve the desired viscosity and form a gel. The in vitro antibacterial tests of TTO-LNF showed promising inhibitory effects toward both Gram-negative and Gram-positive bacteria. In fact, a complete growth inhibition of S. epidermidis was observed when exposed to TTO-LNF and TTO-LNF gel for 24 h, showing better activity than antibiotic kanamycin (25 µg/mL). Additionally, the in vitro release study showed a sustained release profile with a 50% release in 24 h, which could be benefi...Continue Reading

References

Aug 1, 1993·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·T J FranzS D Gettings
Oct 1, 1995·Contact Dermatitis·I Effendy, H I Maibach
Mar 29, 2000·Journal of Applied Microbiology·S D CoxS G Wyllie
Oct 14, 2003·International Journal of Toxicology·Robert E Osterberg, Norman A See
Apr 10, 2004·Advances in Colloid and Interface Science·O Sonneville-AubrunF L'Alloret
Jan 19, 2006·Clinical Microbiology Reviews·C F CarsonT V Riley
Mar 21, 2006·Journal of the American Academy of Dermatology·Lawrence F EichenfieldUNKNOWN Cutivate Lotion Study Group
Jul 19, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jürgen ReichlingUlrich F Schaefer
Aug 31, 2006·The Journal of Pediatrics·Adelaide A HebertDavid B Allen
May 31, 2007·The Australasian Journal of Dermatology·Tim RutherfordBruce Tate
Oct 29, 2008·Antimicrobial Agents and Chemotherapy·Christine M Toutain-KiddMichael E Zegans
Jan 17, 2009·AAPS PharmSciTech·Adnan AzeemSushama Talegaonkar
May 19, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·B MishraSanjay Tiwari
Sep 25, 2012·International Journal of Dermatology·Nader PazyarAfshin Kazerouni
May 24, 2014·The AAPS Journal·Lawrence X YuJanet Woodcock
Jan 21, 2016·The American Journal of Tropical Medicine and Hygiene·Jackson ThomasKavya E Baby
Jan 29, 2016·Drug Development and Industrial Pharmacy·Priyam SinhaNarayan Prasad Yadav
Mar 2, 2016·Drug Development and Industrial Pharmacy·Sang Gon LeeYoung Wook Choi
May 14, 2016·Contact Dermatitis·Anton C de Groot, Erich Schmidt
Nov 5, 2016·International Journal of Pharmaceutics·Ankit ParikhXin-Fu Zhou
Dec 7, 2016·Frontiers in Microbiology·Christina K NielsenRikke L Meyer
Dec 19, 2017·Drug Development and Industrial Pharmacy·Ga-Hui OhYoung-Joon Park
Apr 24, 2018·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Roqya Najafi-TaherAmir Amani
Jul 18, 2018·Drug Design, Development and Therapy·Ankit ParikhXin-Fu Zhou
Oct 15, 2019·Preventive Nutrition and Food Science·Manish KumarChandra Prakash Jain
Aug 26, 2020·ACS Applied Materials & Interfaces·Hanif HaidariKrasimir Vasilev

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Citations

Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Faiyaz ShakeelSultan Alshehri

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Methods Mentioned

BETA
Dynamic Light Scattering

Software Mentioned

Expert
QbD
TEM
LC solution Chromopac
Design
Transcutol

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