Quality Control Practices for Chemistry and Immunochemistry in a Cohort of 21 Large Academic Medical Centers

American Journal of Clinical Pathology
Matthew W RosenbaumKent B Lewandrowski

Abstract

In the United States, minimum standards for quality control (QC) are specified in federal law under the Clinical Laboratory Improvement Amendment and its revisions. Beyond meeting this required standard, laboratories have flexibility to determine their overall QC program. We surveyed chemistry and immunochemistry QC procedures at 21 clinical laboratories within leading academic medical centers to assess if standardized QC practices exist for chemistry and immunochemistry testing. We observed significant variation and unexpected similarities in practice across laboratories, including QC frequency, cutoffs, number of levels analyzed, and other features. This variation in practice indicates an opportunity exists to establish an evidence-based approach to QC that can be generalized across institutions.

References

Oct 13, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Abdurrahman Coskun
May 10, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Andrew WilsonBrian Jackson
Feb 24, 2012·Clinical Chemistry·Curtis A ParvinJohn C Yundt-Pacheco
Mar 23, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Jiakai LiuTze Ping Loh

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Citations

Dec 6, 2018·American Journal of Clinical Pathology·James O Westgard, Sten A Westgard
Jul 3, 2019·Clinical Chemistry·Tony BadrickUNKNOWN International Federation of Clinical Chemistry, and Laboratory Medicine Committee on Analytical Quality
Sep 11, 2020·The Journal of Applied Laboratory Medicine·David P Ng, Daniel S Herman
Mar 25, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Huub H van Rossum, Daan van den Broek
Jun 4, 2020·Critical Reviews in Clinical Laboratory Sciences·Tony BadrickUNKNOWN International Federation of Clinical Chemistry and Laboratory Medicine Committee on Analytical Quality
Mar 11, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Huub H van RossumTony C Badrick
May 10, 2021·Clinical Biochemistry·Tony Badrick
Jun 2, 2021·The Journal of Applied Laboratory Medicine·Matthew FeldhammerJames H Nichols
Sep 25, 2021·Clinical Chemistry·Daniel S HermanThomas J S Durant

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