Quality of compounded hydrocortisone capsules used in the treatment of children

European Journal of Endocrinology
Uta NeumannOliver Blankenstein

Abstract

Due to the lack of paediatric-licensed formulations, children are often treated with individualized pharmacy-compounded adult medication. An international web-based survey about the types of medication in children with adrenal insufficiency (AI) revealed that the majority of paediatric physicians are using pharmacy-compounded medication to treat children with AI. Observations of loss of therapy control in children with congenital adrenal hyperplasia with compounded hydrocortisone capsules and regained control after prescribing a new hydrocortisone batch led to this 'real world' evaluation of pharmacy-compounded paediatric hydrocortisone capsules. Capsule samples were collected randomly from volunteering parents of treated children suffering from congenital adrenal hyperplasia from all over Germany. Analysis of net mass and hydrocortisone content by high-performance liquid chromatography with ultraviolet (HPLC-UV) detection method was performed based on the European Pharmacopeia. In a total of 61 batches that were sent, 5 batches could not be analysed because of missing dose information, insufficient number of capsules or were not possible to be evaluated. Fifty-six batches containing 1125 capsules were evaluated. 21.4% of the b...Continue Reading

References

Sep 20, 2012·The Journal of Clinical Endocrinology and Metabolism·Gabriela P FinkielstainDeborah P Merke
Mar 26, 2013·Drugs in R&D·Jennifer GudemanMichael Randell
Jun 1, 2014·The Journal of Clinical Endocrinology and Metabolism·T S HanUNKNOWN United Kingdom Congenital Adrenal Hyperplasia Adult Study Executive (CaHASE)

❮ Previous
Next ❯

Citations

Oct 13, 2018·Clinical Endocrinology·Eleni DanielRichard J Ross
Mar 2, 2019·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Bradley S MillerKyriakie Sarafoglou
Oct 14, 2017·The Journal of Clinical Endocrinology and Metabolism·Julia E BarillasPhyllis W Speiser
Feb 13, 2019·Therapeutic Advances in Endocrinology and Metabolism·Alina OpreaPhilippe A Lysy
Aug 18, 2020·Journal of the Endocrine Society·Heba Al-RayessKyriakie Sarafoglou
Apr 16, 2019·F1000Research·Phyllis W Speiser
May 3, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Perrin C White
Oct 3, 2018·The Journal of Clinical Endocrinology and Metabolism·Phyllis W SpeiserPerrin C White
Sep 6, 2020·The Journal of Clinical Endocrinology and Metabolism·Uta NeumannOliver Blankenstein
Mar 7, 2021·Pharmaceuticals·Julius KrauseWerner Weitschies
Apr 4, 2021·Pharmacy : Journal of Pharmacy, Education and Practice·Janosch Klinger, Rolf Daniels
Jun 20, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jennifer J BonnerRichard J Ross
May 8, 2021·Endocrine Reviews·Hedi L Claahsen-van der GrintenPerrin C White

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addison Disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.