Quality of life after curative gastrectomy for gastric cancer in a randomised controlled trial

British Journal of Cancer
C-W WuJ Whang-Peng

Abstract

Quality of life (QOL) was studied in gastric cancer patients treated on a randomised, controlled trial comparing D1 (level 1) with D3 (levels 1, 2 and 3) lymphadenectomy. A total of 221 patients were randomly assigned to D1 (n=110) and D3 (n=111) surgery. Quality-of-life assessments included functional outcomes (a 14-item survey about treatment-specific symptoms) and health perception (Spitzer QOL Index) was performed before and after surgery at disease-free status. Patients suffered from irrelative events such as loss of partners was excluded thereafter. Main analyses were done by intention-to-treat. Thus, 214 D1 (106/110=96.4%) and D3 (108/111=97.3%) R0 patients were assessed. Longitudinal analysis showed that functional outcomes decreased at 6 months after surgery and increased over time thereafter, while health perceptions increased over time in general. On the basis of linear mixed model analyses, patients having total gastrectomy, advanced cancer and hemipancreaticosplenectomy, but not complications had poorer QOL than those without. D1 and D3 patients showed no significant difference in QOL. The results suggest that changes of QOL were largely due to scope of gastric resection, disease status and distal pancreaticosplene...Continue Reading

References

Mar 1, 1992·The British Journal of Surgery·D KorenagaK Sugimachi
Jan 1, 1981·Journal of Chronic Diseases·W O SpitzerB R Catchlove
Jul 1, 1995·World Journal of Surgery·K MaruyamaK Okajima
Mar 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D F CellaJ Brannon
Apr 16, 1998·The European Journal of Surgery = Acta Chirurgica·H U ZierenJ M Müller
Sep 25, 1998·World Journal of Surgery·J DaviesI Martin
Feb 18, 1999·The American Journal of Gastroenterology·J SvedlundL Lundell
Mar 23, 1999·World Journal of Surgery·A Thybusch-BernhardtB Kremer
Apr 2, 2002·Gynecologic Oncology·E GreimelE Pongratz
Mar 3, 2004·The British Journal of Surgery·C W WuJ Whang-Peng
Apr 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H H HartgrinkM Sasako
Feb 18, 2005·Clinical Oncology : a Journal of the Royal College of Radiologists·S C ErridgeA Gregor
Dec 22, 2005·World Journal of Surgery·Chew-Wun WuJacqueline Whang-Peng
Apr 1, 2006·The Lancet Oncology·Chew-Wun WuJacqueline Whang-Peng

❮ Previous
Next ❯

Citations

Feb 2, 2010·BMC Cancer·Do Hyoung LimWon Ki Kang
Jan 29, 2013·Canadian Journal of Surgery. Journal Canadien De Chirurgie·Céline Zacharias, Thomas Zacharias
Jul 28, 2016·Chinese Journal of Cancer·Hironori ShiozakiJaffer A Ajani
Sep 24, 2013·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·Y Zhang, S Tian
Aug 28, 2015·Surgical Endoscopy·Jennifer StraatmanDonald L van der Peet
Oct 25, 2012·Journal of Gastric Cancer·Horyon KongWansik Yu
Oct 16, 2010·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Seung Soo LeeWansik Yu
Nov 26, 2010·The British Journal of Surgery·Y KurokawaUNKNOWN Japan Clinical Oncology Group
Nov 26, 2010·World Journal of Surgery·Daisuke KobayashiAkimasa Nakao
Jan 10, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·In Cheol HwangTae-Sung Sohn
Jul 6, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Alyson L MaharLucy K Helyer
Oct 14, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Shuji TakiguchiUNKNOWN Osaka University Clinical Research Group for Gastroenterological Study
Oct 12, 2012·Annals of Surgical Oncology·Johan L DikkenJohanna W van Sandick
Jun 8, 2015·Current Opinion in Oncology·Gianmauro NumicoNicola Silvestris
Oct 20, 2018·BMJ Open·Bilal AlkhaffafAnne-Marie Glenny
Dec 17, 2011·World Journal of Surgery·Masaru HayamiShingo Kameoka
Mar 15, 2016·World Journal of Gastroenterology : WJG·Tohru TaniMasaji Tani
Oct 22, 2016·World Journal of Surgery·Hideo KonishiKatsuhiko Yanaga
Jan 20, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Paul J KaranicolasMurray F Brennan
Jan 3, 2021·Surgery Today·Takaomi HagiYuichiro Doki
Jan 4, 2021·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Sang Il YounHyung-Ho Kim
Jun 1, 2021·Gastrointestinal Endoscopy Clinics of North America·Ian Solsky, Haejin In
Jun 19, 2021·World Journal of Clinical Cases·Rodrigo Nascimento PinheiroGaspar de Jesus Lopes Filho

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.