Quality of life among formerly treated childhood-onset growth hormone-deficient adults: a comparison with unaffected siblings

The Journal of Clinical Endocrinology and Metabolism
D E SandbergD E Alliger

Abstract

Several studies have investigated the quality of life (QOL) of GH-deficient (GHD) adults who, as children, had been treated with GH. Variable findings are probably related to sample heterogeneity and disparate research methodologies and designs, particularly the choice of control or comparison groups. In addition to comparing a relatively large sample to questionnaire norms, the present study is the first to compare the QOL adjustment of GHD patients to that of same sex siblings. A total of 140 former patients (76% of those eligible; mean age, 26 yr; n = 95 isolated GHD, n = 45 multiple pituitary hormone deficiencies; 117 males and 23 females) and 53 same sex siblings (84% participation), 18 yr and older, participated in the telephone questionnaire survey. The majority of interviews with GHD patients (78%) and siblings (87%) were conducted blind to the subject's clinical status. Comparisons between GHD patients and norms for standardized questionnaires indicated both better and worse functioning in several domains. In contrast, very limited differences were detected between GHD cases and same sex siblings. Isolated GHD patients were functioning better than those with multiple pituitary hormone deficiencies, but the effect sizes...Continue Reading

References

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Citations

Dec 4, 2009·International Journal of Pediatric Endocrinology·Arlan L Rosenbloom
Sep 6, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Toshiaki TanakaPierre C Sizonenko
Sep 20, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Roger AbsUNKNOWN KIMS Study Group
May 1, 2013·The Journal of Pediatrics·Amira Al-UzriUNKNOWN Chronic Kidney Disease in Children Study Group
Oct 17, 2015·PloS One·Grit SommerUNKNOWN Swiss Society for Paediatric Endocrinology and Diabetology (SGPED)

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