Quality of life and acute toxicity of radiotherapy in women with gynecologic cancer: a prospective longitudinal study

Archives of Gynecology and Obstetrics
Ana F VazSérgio B Esteves

Abstract

To investigate the incidence of acute toxicity of radiotherapy, evaluate quality of life (QOL) and identify its predictors in a cohort of gynecologic cancer patients. A longitudinal prospective study was conducted including 107 women between the ages of 18 and 75 years with cervical or endometrial cancer. Acute toxicity was evaluated according to the Common Toxicity Criteria and the Radiotherapy Oncology Group toxicity criteria. QOL was measured with World Health Organization's Quality of Life instrument-abbreviated version (WHOQOL-BREF) before and at completion of radiotherapy and during the first clinical follow-up visit. QOL scores were assessed by ANOVA for repeat measures. Percentage variation of QOL scores from the time before radiotherapy to the first clinical visit was compared with control variables by the Wilcoxon test. Multiple linear regression analysis was used to identify predictors of QOL. Ninety-five women completed the three QOL assessments. The incidence of acute toxicity was 93.5% and the most common complaint was lower gastrointestinal (79.6%). A significant increase in QOL scores was observed in the physical and psychological domains, as well as general health and overall QOL. Upper gastrointestinal toxicit...Continue Reading

References

Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J D CoxT F Pajak
Feb 1, 1995·Acta Obstetricia Et Gynecologica Scandinavica·A ByeS Kaasa
Oct 1, 1993·The American Journal of Medicine·E YeohB Chatterton
Aug 5, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·P HugueninC Glanzmann
Aug 19, 1999·Cancer Nursing·M Eisemann, A Lalos
Jan 7, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·E WeissM Bamberg
Apr 12, 2000·International Journal of Radiation Oncology, Biology, Physics·A TrottiW Curran
Oct 31, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D KiliçA Dursun
Oct 5, 2001·Gynecologic Oncology·Y M ChanL C Wong
Dec 1, 2001·International Journal of Radiation Oncology, Biology, Physics·C L CreutzbergUNKNOWN PORTEC Study Group. The Postoperative Radiation Therapy in Endometrial Carcinoma
Apr 2, 2002·Gynecologic Oncology·E GreimelE Pongratz
Jul 30, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Barbara A Jereczek-FossaJacek Jassem
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Apr 26, 2005·International Journal of Nursing Studies·Karin AhlbergFannie Gaston-Johansson
Apr 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathleen EllChristy Russell
May 3, 2005·Gynecologic Oncology·Lari WenzelNoreen Aziz
May 20, 2005·American Journal of Obstetrics and Gynecology·Lijia ZhuOlufemi Olatunbosun
Sep 22, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J M de GrootG M Devins
Oct 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael FrumovitzDiane C Bodurka
Nov 22, 2005·The Breast Journal·Délio Marques CondeEdson Zangiacomi Martinez
Jan 4, 2006·American Journal of Obstetrics and Gynecology·Georgina L JonesStephen H Kennedy
Jan 31, 2006·Indian Journal of Medical Sciences·Naveet WigSunil Kumar Agarwal
Mar 28, 2006·International Journal of Radiation Oncology, Biology, Physics·Benjamin MovsasDeborah Watkins-Bruner
Jun 15, 2007·Archives of Gynecology and Obstetrics·Ana Francisca VazSérgio Barros Esteves

❮ Previous
Next ❯

Citations

Mar 29, 2011·Archives of Gynecology and Obstetrics·Ana Francisca VazAarão Mendes Pinto-Neto
Jul 29, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Andrea GaluppiPierandrea De Iaco
Jun 11, 2011·Journal of Advanced Nursing·Ying Chun ZengAlice Yuen Loke
Nov 27, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·C PisaniM Krengli
Jun 28, 2014·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Mei-Chuan HungJung-Der Wang
Mar 3, 2009·International Journal of Radiation Oncology, Biology, Physics·Tien LeMichael Fung-Kee-Fung
Apr 23, 2014·Japan Journal of Nursing Science : JJNS·Yu Huan ChaoKai Wei K Wang
Mar 23, 2010·Health and Quality of Life Outcomes·Ying Chun ZengAlice Y Loke
Mar 26, 2015·Revista latino-americana de enfermagem·Simone Mara de Araújo FerreiraAna Maria de Almeida
Jun 8, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Guler YavasCetin Celik
Apr 8, 2011·Menopause : the Journal of the North American Menopause Society·Ana F VazSérgio B Esteves
Apr 5, 2011·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Anna EnblomSussanne Börjeson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.