Quality of life and antihypertensive therapy in men. A comparison of captopril with enalapril. The Quality-of-Life Hypertension Study Group

The New England Journal of Medicine
M A TestaN K Hollenberg

Abstract

We conducted a multicenter trial comparing two angiotensin-converting-enzyme inhibitors to determine whether effects on quality of life during antihypertensive therapy are uniform within this pharmacologic class of agents, and to relate the effects of the drugs on quality of life to objective adverse events, such as the loss of a job or the death of a spouse. After a four-week washout period when they received placebo, 379 men with mild-to-moderately-severe hypertension were randomly assigned to receive captopril (25 to 50 mg twice daily, with or without hydrochlorothiazide) or enalapril (5 to 20 mg per day, with or without hydrochlorothiazide) for 24 weeks. Blood pressure, quality of life, and life events were monitored. Differences between treatments were evaluated by calibrating measures of quality of life with objective life events. Throughout the treatment period, no differences were found in blood pressure, frequency of withdrawal of patients from the study, or major side effects. Patients treated with captopril had more favorable changes in overall quality of life, general perceived health, vitality, health status, sleep, and emotional control (P < 0.05 for each). The changes varied according to the quality of life at ba...Continue Reading

References

Dec 3, 1976·Science·J G Rabkin, E L Struening
Jul 1, 1991·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·D G Waller
Jan 1, 1991·Journal of Clinical Epidemiology·M R TuleyC A McMahan
Mar 1, 1991·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·N K HollenbergG H Williams
Jan 19, 1990·JAMA : the Journal of the American Medical Association·J T EdelsonL Goldman
Apr 5, 1989·Journal of the National Cancer Institute·C M MoinpourJ Crowley
Jan 1, 1989·Journal of Clinical Epidemiology·P K TandonR P Schwarz
Jan 1, 1988·Postgraduate Medical Journal·L Kreel
Jun 26, 1986·The New England Journal of Medicine·S H CroogG H Williams
Dec 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R D Gelber, A Goldhirsch
Jan 1, 1987·Journal of Chronic Diseases·G GuyattG Norman
Sep 1, 1968·Journal of Health and Social Behavior·G W Brown, J L Birley
Aug 1, 1967·Journal of Psychosomatic Research·T H Holmes, R H Rahe
Aug 1, 1984·Psychological Medicine·E S PaykelC N Taylor
Sep 1, 1984·Psychosomatic Medicine·S E LockeR M Williams
Aug 12, 1983·JAMA : the Journal of the American Medical Association·C D JenkinsM D Klein
Jan 1, 1984·Psychosomatic Medicine·J K Kiecolt-GlaserR Glaser
Aug 23, 1984·The New England Journal of Medicine·B R CassilethA N Tenaglia
Mar 1, 1980·Social Science & Medicine. Medical Psychology & Medical Sociology·C A Haney
Jun 1, 1980·Social Science & Medicine. Medical Geography·W Edmundson
Jan 9, 1992·PharmacoEconomics·C J Bulpitt, A E Fletcher

❮ Previous
Next ❯

Citations

Aug 10, 1999·Diabetes/metabolism Research and Reviews·R R Rubin, M Peyrot
Jun 1, 1997·Journal of Clinical Pharmacology·T BentalM Ravid
Dec 1, 1993·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·M J Naughton, I Wiklund
Dec 1, 1993·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·R D HaysD Revicki
Dec 1, 1993·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·D A Revicki, R M Kaplan
Jun 1, 1996·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·K J RoseR S McLachian
Feb 1, 1995·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·C JenkinsonJ Gordon
Feb 1, 1995·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·R A BerzonH H Tilson
Apr 1, 1996·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·J SvedlundL Lundell
Aug 1, 1996·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·D A RevickiL Howland
Sep 22, 1995·Pharmacy World & Science : PWS·S Dedhiya, S X Kong
Aug 1, 1995·Journal of General Internal Medicine·E J Pérez-StableD Feigal
Dec 1, 2011·Nanoscale Research Letters·Suguna Lakshmi MaduraiBoreddy Sr Reddy
Dec 6, 2001·Current Hypertension Reports·M I Nunes
Feb 1, 1995·Social Science & Medicine·N E BushK M Sullivan
Oct 1, 1995·Journal of the American College of Cardiology·J TsevatT H Lee
Jan 1, 1995·European Psychiatry : the Journal of the Association of European Psychiatrists·P Bech
Mar 22, 2002·European Journal of Pharmacology·Paul R Gard
Nov 5, 1998·International Journal of Nursing Studies·E RukholmJ Potts
Jul 10, 1999·Social Science & Medicine·I B Wilson
Feb 29, 2000·International Journal of Pharmaceutics·A O Nur, J S Zhang
Sep 3, 2002·Journal of Pain and Symptom Management·Nathaniel Katz
Feb 13, 2001·Journal of Clinical Epidemiology·C Bardage, D G Isacson
Feb 19, 2003·Journal of Clinical Epidemiology·Samuel WiebeCasey Sidwell
Nov 1, 1996·Journal of Clinical Epidemiology·W F LawrenceB E Klein
Sep 2, 1999·Journal of Evaluation in Clinical Practice·M Berk, M L Janet
Apr 1, 1993·The New England Journal of Medicine·S Oparil
Aug 12, 1993·The New England Journal of Medicine·D R Waud
Mar 28, 1996·The New England Journal of Medicine·M A Testa, D C Simonson
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·M N SackD P Kelly
Mar 1, 1996·Journal of Biopharmaceutical Statistics·S C Chow, F Y Ki
Jun 24, 2000·The Journal of Trauma·M G PetersonC N Cornell
Aug 14, 2009·Clinical and Experimental Pharmacology & Physiology·A S MecawiL C Reis
Jun 5, 1998·Acta Neurologica Scandinavica·J L RibeiroA Martins da Silva

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.