Quality of life and cancer pain: satisfaction and side effects with transdermal fentanyl versus oral morphine

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
R PayneR Mahmoud

Abstract

To compare pain-related treatment satisfaction, patient-perceived side effects, functioning, and well-being in patients with advanced cancer who were receiving either transdermal fentanyl (Duragesic, Janssen Pharmaceuticals, Titusville, NJ) or sustained-release oral forms of morphine (MS Contin, Perdue Frederick Co, Norwalk, CT, or Oramorph SR, Roxanne Laboratories, Columbus, OH). A total of 504 assessable cancer patients participated in this cross-sectional, quality-of-life study. Relevant elements of four validated scales were used--the Functional Assessment of Cancer Therapy-General (FACT-G) scale, the Brief Pain Inventory (BPI), the Medical Outcomes Study (MOS) questionnaire, and the Memorial Symptom Assessment Scale (MSAS)--as well as original scales that were developed and validated for this study. The majority of patients in both treatment groups had late-stage (IV/D) cancer. Patients who received transdermal fentanyl were more satisfied overall with their pain medication than those who received sustained-release oral forms of morphine (P = .035). Fentanyl patients also experienced a significantly lower frequency (P < .002) and impact (P < .001) of pain medication side effects. These results occurred despite the fact tha...Continue Reading

Associated Clinical Trials

Citations

Feb 11, 2000·Clinical Pharmacokinetics·S GrondK A Lehmann
Oct 6, 2000·Journal of the American Veterinary Medical Association·J N FranksD M Boothe
Jun 11, 2002·Palliative Medicine·L RadbruchK A Lehmann
Jul 13, 2002·Expert Review of Anticancer Therapy·S Mercadante
Oct 30, 2003·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Craig A KornickEugenie A M T Obbens
May 25, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bradley J MonkUNKNOWN Gynecologic Oncology Group Study
Nov 30, 2006·Pain Practice : the Official Journal of World Institute of Pain·Kenneth C Jackson, Brad Stanford
Sep 22, 2007·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Shefali AgarwalSrinivasa N Raja
Mar 21, 2008·European Journal of Pain : EJP·Sebastiano MercadanteSalvatore Mangione
Dec 25, 2012·The American Journal of Hospice & Palliative Care·Osamu TakakuwaAkio Niimi
Aug 1, 2013·Current Gastroenterology Reports·Gyanprakash A KetwarooAnthony Lembo
Mar 9, 2004·Der Schmerz·A SchwarzerE Klaschik
Sep 25, 2003·International Journal of Cancer. Journal International Du Cancer·Kyriaki MystakidouLambros Vlahos
Jan 6, 2001·The American Journal of Hospice & Palliative Care·R E Enck
Sep 24, 2004·Pharmacoepidemiology and Drug Safety·N S Breekveldt-PostmaR M C Herings
Feb 28, 2006·Journal of Palliative Medicine·David Casarett
Dec 22, 2007·Journal of Palliative Medicine·James F Cleary
Dec 25, 2009·Drugs·Sina GrapeBarbara S Schug
Sep 20, 2008·Pediatric Blood & Cancer·Giorgio AttinàRiccardo Riccardi
Oct 1, 2010·Reviews in Pain·Rohan Hasmukh Vithlani, Ganesan Baranidharan
Nov 27, 2019·Journal of Palliative Medicine·Michael SmythMarie-Claude Gregoire
Oct 6, 2001·The Clinical Journal of Pain·S M SkevingtonA C Williams
Jun 16, 2001·The American Journal of Hospice & Palliative Care·L D Wrede-Seaman
Jul 4, 2001·Drugs·C Ripamonti, E D Dickerson
May 24, 2007·Japanese Journal of Clinical Oncology·Katri Elina Clemens, Eberhard Klaschik
Dec 1, 2002·Expert Review of Pharmacoeconomics & Outcomes Research·Anne Brédart, Andrew Bottomley
Sep 18, 2001·European Journal of Pain : EJP·C P BleekerB J Crul
Aug 4, 2009·International Journal of Palliative Nursing·Margaret Gibbs
Aug 31, 2007·Drugs & Aging·Sebastiano Mercadante, Edoardo Arcuri
Feb 18, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Carla RipamontiFranco De Conno

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.