Quality of life and cost-effectiveness of levonorgestrel-releasing intrauterine system versus hysterectomy for treatment of menorrhagia: a randomised trial

Lancet
Ritva HurskainenJ Paavonen

Abstract

Heavy menstrual blood loss is a common reason for women to seek medical care. The levonorgestrel-releasing intrauterine system (IUS) is an effective medical treatment for menorrhagia. We report a randomised comparison of this approach with hysterectomy in terms of the quality of life of women with menorrhagia and cost-effectiveness. Of 598 women referred with menorrhagia to five university hospitals in Finland, 236 were eligible and agreed to take part. They were randomly assigned treatment with the levonorgestrel-releasing IUS (n=119) or hysterectomy (n=117). The amount of menstrual blood loss was objectively measured. The primary outcome measure was health-related quality of life at 12-month follow-up. Analyses were by intention to treat. In the group assigned the levonorgestrel-releasing IUS, 24 (20%) women had had hysterectomy and 81 (68%) continued to use the system at 12 months. Of the women assigned to the hysterectomy group, 107 underwent the operation. Health-related quality of life improved significantly in both the IUS and hysterectomy groups (change 0.10 [95% CI 0.06-0.14] in both groups) as did other indices of psychological wellbeing. There were no significant differences between the treatment groups except that w...Continue Reading

References

Jun 1, 1992·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·S L WangJ Gao
Jan 1, 1991·International Journal of Technology Assessment in Health Care·M F Drummond, L Davies
Aug 1, 1991·British Journal of Obstetrics and Gynaecology·A CoulterA Tulloch
Aug 1, 1990·British Journal of Obstetrics and Gynaecology·J K Andersson, G Rybo
Sep 1, 1985·Maturitas·N L McCoy, J M Davidson
Oct 1, 1993·Health Economics·R D HaysR M Mazel
May 1, 1997·British Journal of Obstetrics and Gynaecology·J W Barrington, P Bowen-Simpkins
Jul 1, 1997·American Journal of Obstetrics and Gynecology·P G CrosignaniM Meschia
Nov 1, 1994·Health Economics·M A Koopmanschap, F F Rutten
Mar 25, 1998·Acta Obstetricia Et Gynecologica Scandinavica·R HurskainenJ Paavonen
May 7, 1998·BMJ : British Medical Journal·A Prentice

❮ Previous
Next ❯

Citations

Oct 12, 2007·International Journal of Behavioral Medicine·Marko ElovainioRitva Hurskainen
Nov 20, 2008·Archives of Gynecology and Obstetrics·Husnu GorgenAhmet Cetin
Jun 30, 2005·Best Practice & Research. Clinical Obstetrics & Gynaecology·Nassera S Banu, Isaac T Manyonda
Sep 14, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Dominique Van SchoubroeckDirk Timmerman
Mar 24, 2004·Maturitas·Marlies Y BongersHans A M Brölmann
Apr 23, 2004·Trends in Molecular Medicine·Suman BiswasDavid A Phoenix
May 10, 2003·Fertility and Sterility·Vera GrigorievaAnton Mikhailov
May 3, 2003·Lancet·Martin C Sowter
Mar 18, 2003·Social Science & Medicine·Sirkku VuormaJuha Teperi
Jul 15, 2009·Journal de gynécologie, obstétrique et biologie de la reproduction·O Graesslin, E Derniaux
Feb 5, 2003·Patient Education and Counseling·Sirkku VuormaErkki Kujansuu
Oct 11, 2003·BJOG : an International Journal of Obstetrics and Gynaecology·Janelle SeymourKevin Cooper
May 16, 2002·Haemophilia : the Official Journal of the World Federation of Hemophilia·J E Siegel, P A Kouides
Oct 18, 2002·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·P InkiJ Paavonen
Jan 11, 2013·The New England Journal of Medicine·Janesh GuptaUNKNOWN ECLIPSE Trial Collaborative Group
Nov 10, 2004·Current Opinion in Obstetrics & Gynecology·Ritva Hurskainen, Jorma Paavonen
Feb 11, 2005·The Nurse Practitioner·Mandy J Johnson, Katherine W Morgan
Oct 12, 2005·The Nurse Practitioner·Linda D Bradley
Feb 8, 2002·Obstetrical & Gynecological Survey·David Hubacher, David A Grimes
Jul 3, 2004·Current Opinion in Obstetrics & Gynecology·T Justin Clark
Apr 5, 2005·Clinical Obstetrics and Gynecology·Akas Jain, Nanette Santoro
Apr 5, 2005·Clinical Obstetrics and Gynecology·Rameet H Singh, Paul Blumenthal
Aug 27, 2005·Obstetrical & Gynecological Survey·Jeffrey T Jensen
Nov 6, 2007·Clinical Obstetrics and Gynecology·Camaryn ChrismanVanessa K Dalton
Dec 25, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Hala F RizkallaColm O'Herlihy
May 31, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J KössiM Luostarinen
Dec 4, 2003·BMJ : British Medical Journal·Anne Lethaby, Cindy Farquhar
Aug 27, 2009·Therapeutics and Clinical Risk Management·Megan N Beatty, Paul D Blumenthal
Mar 6, 2008·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Miriam Santer
Jun 22, 2001·Lancet·B W MolH A Brölmann
Jan 9, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Maram DarwishTamara Mohamed-Taysir
Mar 3, 2011·Radiology·Fiona M FennessyJ Shannon Swan
Aug 21, 2009·Archives of Gynecology and Obstetrics·Sérgio Simões de SouzaAgnaldo Lopes Silva Filho
Sep 1, 2005·Women's Health·Regine Sitruk-Ware, Pirjo Inki
Oct 20, 2005·Journal of Women's Health·Josephine MauskopfJaneen Duchane
Nov 4, 2011·Journal of Women's Health·Sonal ChaudhryMichelle Warren

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.