Quality of life and healthcare resource use associated with angiographic vasospasm after aneurysmal subarachnoid hemorrhage

Stroke; a Journal of Cerebral Circulation
R Loch MacdonaldStephan A Mayer

Abstract

In this analysis of data from a large clinical trial in aneurysmal subarachnoid hemorrhage, the impact of angiographic vasospasm (aVSP) on specific patient outcomes and inpatient healthcare resource use was assessed. This was a post hoc analysis of exploratory end points collected for 409 patients with aneurysmal subarachnoid hemorrhage in the Clazosentan to Overcome Neurological Ischemia and Infarction Occurring After Subarachnoid Hemorrhage (CONSCIOUS-1) trial. Central reviewers graded severity of aVSP as none, mild, moderate, or severe based on comparison of catheter angiograms obtained at baseline and 7 to 11 days after aneurysmal subarachnoid hemorrhage. Assessments of cognitive status (Mini-Mental State Examination) and patient-relevant outcomes (EuroQol total score and visual analog scale and Functional Status Examination) were administered at Week 12. The relationship between severity of aVSP and these end points as well as inpatient healthcare resource use (intensive care, general ward, and total hospital lengths of stay) was assessed using univariate and multivariate analyses. Cognitive status and all patient-relevant outcome measures varied significantly (P<0.0001) with severity of aVSP (mean for severe aVSP versus n...Continue Reading

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Feb 26, 2011·Stroke; a Journal of Cerebral Circulation·R Webster CrowleyR Loch Macdonald

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Citations

Jul 28, 2013·Acta neurochirurgica·Martin N StienenUNKNOWN Swiss SOS study group
Aug 10, 2019·Stroke; a Journal of Cerebral Circulation·Stephan A MayerRandall T Higashida
May 28, 2019·Neurocritical Care·Martin N StienenUNKNOWN Unruptured Intracranial Aneurysms and SAH CDE Project Investigators
Apr 7, 2018·Frontiers in Molecular Neuroscience·Jenna L LeclercSylvain Doré
Oct 17, 2020·Critical Care Explorations·Katherine M CliffordVibha Mohindra

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