Quality of Life and Persistent Symptoms After Uncomplicated Acute Diverticulitis

Diseases of the Colon and Rectum
S T van DijkDutch Diverticular Disease (3D) Collaborative Study Group

Abstract

Although acute diverticulitis and its recurrence are well studied, little is known about the period after these attacks have passed. Many patients appear to be affected by persistent symptoms that impair quality of life. The few published studies on this topic are mostly limited by the lack of CT confirmation of the acute diverticulitis diagnosis, low numbers of patients, or cross-sectional design. This study longitudinally evaluated quality of life and symptoms after antibiotic or observational treatment of uncomplicated acute diverticulitis. This was an observational study of randomized clinical trial data. This study was conducted at a single tertiary care center. Patients with CT-proven, primary, left-sided, uncomplicated acute diverticulitis were randomly assigned to observational or antibiotic treatment. Quality of life was assessed using questionnaires (EuroQol 5D, Short Form-36, and Gastrointestinal Quality of Life Index) at baseline and 3, 6, 12, and 24 months after random assignment. Patients were considered to have persistent symptoms when specific quality-of-life scores at the 12- and 24-month follow-ups were among the lowest 16% of scores measured in a healthy reference group. A total of 528 patients were included....Continue Reading

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Citations

Mar 29, 2020·Nature Reviews. Disease Primers·Antonio TursiSilvio Danese
May 10, 2020·Diseases of the Colon and Rectum·Jason HallUNKNOWN Prepared on behalf of the Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons
Apr 18, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·N AzharJ K Schultz
Jan 12, 2021·The Journal of Surgical Research·Jessica N CohanElissa M Ozanne
Oct 21, 2020·Current Problems in Surgery·Alexander T HawkinsAmy L Lightner
Jul 29, 2019·Cellular and Molecular Gastroenterology and Hepatology·Michael CamilleriAnne F Peery
Jun 18, 2021·Annals of Surgical Treatment and Research·Youn Young ParkChinock Cheong
Jan 18, 2022·Annals of Internal Medicine·Amir QaseemUNKNOWN Clinical Guidelines Committee of the American College of Physicians*
Apr 20, 2021·European Journal of Gastroenterology & Hepatology·Antonio TursiGiovanni Brandimarte

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