Quality of life as an endpoint in EORTC clinical trials. European Organization for Research and Treatment for Cancer

Statistics in Medicine
G M KiebertN Aaronson

Abstract

For more than 30 years the European Organization for Research and Treatment for Cancer (EORTC) has conducted, co-ordinated, and stimulated research on the experimental and clinical bases of treatment of cancer and related problems. For more than a decade the EORTC has included quality of life as an outcome measure in some of its trials. The number of clinical studies that include QOL as an evaluation endpoint has increased rapidly in the last few years, and is still increasing steadily. This necessitated a careful and critical evaluation of procedures and results so far in order to generate appropriate guidelines and procedures for incorporating QOL issues in all stages of the clinical trial process, including protocol writing, data collection, data analysis, and reporting of results. This paper provides an overview of the types and the design of studies, data management of quality of life assessment, compliance, missing data and lessons learned during the past years with respect to QOL assessments in the EORTC studies.

Citations

Nov 30, 2019·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·E ChartonA Anota
Aug 19, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Caroline Bascoul-MolleviAmélie Anota
Jun 19, 2004·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Patricia J HollenCynthia N Rittenberg
Jul 27, 2005·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Jennifer L SteelBrian I Carr
Sep 1, 2001·Journal of Advanced Nursing·L Hakamies-BlomqvistC Blomqvist
Mar 21, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Marjan WestermanGerrit van der Wal
Oct 1, 2005·Expert Review of Pharmacoeconomics & Outcomes Research·Linda E Carlson, Sheila Garland
Jan 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E P WrightA Cull
Sep 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S B DetmarJ H Schornagel
Jul 21, 2021·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Amélie AnotaVirginie Westeel

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