Quality of Life, Functional Outcomes, and Wound Complications in Patients with Soft Tissue Sarcomas Treated with Preoperative Chemoradiation: A Prospective Study

Annals of Surgical Oncology
Justin D RivardLloyd A Mack

Abstract

Preoperative irradiation reduces local recurrence of soft tissue sarcomas (STSs), but major wound complication rates approach 25-35 %. Using a novel neoadjuvant chemoradiation protocol, we prospectively documented functional outcomes and quality of life (QOL) and hypothesized a lower major wound complication rate. Patients with STS deep to muscular fascia were treated with 3 days of doxorubicin (30 mg/day) and 10 days of irradiation (300 cGy/day) followed by limb-sparing surgery. Wound complications were assessed, and functional assessment and QOL were followed prospectively using the Toronto Extremity Salvage Score (TESS), Musculoskeletal Tumor Society (MSTS), and Short Form (SF)-36 questionnaires preoperatively and 6 and 12 months postoperatively. Altogether, 52 consecutive patients were accrued during 2006-2011. Overall, 80.8 % of STSs were >5 cm, and 67.3 % involved the lower extremity. Seven (13.5 %) major wound complications occurred, all requiring reoperation. Preoperative scores for TESS, MSTS, and SF-36 physical (PCS) and mental (MCS) health components were 83.3, 86.7, 40.6, and 49.4, respectively. There were no differences seen 6 months postoperatively. By 12 months, however, patients showed improved functional scores...Continue Reading

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Citations

Jun 23, 2020·Clinical Orthopaedics and Related Research·Koichi OguraJohn H Healey
Mar 27, 2019·Sarcoma·Lesley StoreyRachel M Taylor
Sep 21, 2018·American Society of Clinical Oncology Educational Book·Elizabeth H BaldiniJonathan C Trent
Feb 23, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Koichi OguraJohn H Healey
Mar 20, 2021·Annals of Surgical Oncology·Gilber KaskIan Barner-Rasmussen

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