Quality of life improvements in patients with cervical dystonia following treatment with a liquid formulation of abobotulinumtoxinA (Dysport® )

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
M Simonetta-MoreauW Poewe

Abstract

In patients with cervical dystonia, abobotulinumtoxinA solution for injection (ASI) has been shown to be similarly effective to freeze-dried abobotulinumtoxinA in reducing Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) total scores. In this secondary analysis, quality of life data as evaluated with the Cervical Dystonia Impact Profile (CDIP-58) are presented. This was a double-blind, randomized, active and placebo-controlled study followed by an open-label extension (NCT01261611). In the double-blind phase, patients were randomized (3:3:1) to one cycle of ASI 500 U (n = 156), abobotulinumtoxinA 500 U (n = 159) or placebo (n = 54). Following the double-blind phase, all patients received open-label ASI for up to four cycles. The CDIP-58 total scores were significantly improved at week 4 of the double-blind phase in both the ASI 500 U and abobotulinumtoxinA 500 U groups versus placebo [least squares mean change from baseline of -9.5 (-11.51, -7.45) and -11.2 (-13.2, -9.26) vs. -0.9 (-4.04, 2.14), respectively; both P < 0.0001 vs. placebo]. All CDIP-58 domains contributed to this improvement and benefits were maintained across open-label treatment. Positive correlations were observed between CDIP-58 total score and all...Continue Reading

References

Aug 22, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·I M SkogseidE Kerty
Apr 3, 2010·Parkinsonism & Related Disorders·Daniel TruongUNKNOWN Global Dysport Cervical Dystonia Study Group
Sep 23, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Werner PoewePhilippe Picaut
Feb 1, 2017·Neuropsychiatric Disease and Treatment·Subsai KongsaengdaoNarong Maneeton

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