Quality of life in adult patients with acute myeloid leukemia receiving intensive and prolonged chemotherapy -- a longitudinal study

Leukemia
Andrea SchumacherJ van de Loo

Abstract

Intensification of treatment for acute myeloid leukemia (AML) in adult patients resulted in a substantial improvement in long-term prognosis. Therefore, the assessment of quality of life (QL) of patients undergoing treatment is of growing interest. This study was designed to evaluate QL in patients with AML treated according to the protocol of the German AML-Cooperative Group (Münster, Germany). The EORTC QLQ-C 30 questionnaire was used to analyze QL throughout therapy, evaluating defined specific parameters at 12 different time-points. Sixty-one patients were recruited within the first 30 months of the study. Those 28 patients who have completed the course of inpatient treatment (n=28) are evaluated for changes in the conceptually distinct QL domains: Physical Functioning (P<0.001), Role Functioning (P=0.001), Emotional Functioning (P < 0.001) and Social Functioning (P=0.007) improve significantly from beginning of chemotherapy to the end of inpatient treatment. Individual assessment of Global Health Status and Subjective QL improves significantly over the same time (P< 0.001). At the end of inpatient treatment patients suffer significantly less from fatigue, nausea/emesis, loss of appetite and sleep disturbance (P < 0.001). A...Continue Reading

Citations

Sep 25, 2007·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Debra S BurnsLarry D Cripe
Oct 22, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Abbas H PanjuShabbir M H Alibhai
Jul 23, 2013·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Constantina PapadopoulouMarkus Themessl-Huber
Feb 13, 2002·Leukemia Research·Andrea SchumacherWolfgang E Berdel
Feb 10, 2004·Cancer Treatment Reviews·Alberto RedaelliChris L Pashos
Nov 5, 2005·Leukemia·M KoenigsmannJ Frommer
Jun 13, 2002·Reviews in Clinical and Experimental Hematology·Thomas BüchnerUNKNOWN German AML Co-Operative Group
Nov 19, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Shabbir M H AlibhaiS Nicole Culos-Reed
Jun 25, 2003·Expert Review of Anticancer Therapy·Alberto RedaelliMarc F Botteman
Sep 4, 2007·Critical Reviews in Oncology/hematology·Shabbir M H AlibhaiMark D Minden
Mar 17, 2009·European Journal of Haematology·Anna T JohnsenMogens Groenvold
Nov 7, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Vida Ghodraty-JablooMartine T E Puts
Oct 26, 2005·Critical Reviews in Oncology/hematology·Thomas BüchnerWolfgang Hiddemann
Mar 26, 2015·Oncology Nursing Forum·Ashley Leak BryantBryce B Reeve
Nov 14, 2008·Critical Reviews in Oncology/hematology·Michael KoehlerJoerg Frommer
Apr 27, 2004·Omega·Pam McGrath
Nov 21, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Neha KayasthaThomas W LeBlanc
Jul 12, 2002·Psycho-oncology·Charles MontgomeryKeith Lloyd
Apr 3, 2002·The American Journal of Hospice & Palliative Care·Pam McGrath
Jan 1, 2016·Oncology and Therapy·Erin L TomaszewskiFloortje van Nooten

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