Quality of life in adults with chronic idiopathic urticaria receiving desloratadine: a randomized, double-blind, multicentre, placebo-controlled study

Journal of the European Academy of Dermatology and Venereology : JEADV
J-J GrobJ-P Ortonne

Abstract

To assess the effect of desloratadine on quality of life (QoL) in chronic idiopathic urticaria (CIU). Patients with a history of CIU (pruritus and weals lasting = 6 weeks) were included in this multicentre, randomized, double-blind placebo-controlled study that took place in dermatology centres throughout France. During the study, patients were randomized to receive desloratadine 5 mg daily or placebo for 42 days. Variation of the scores of two QoL dermatology-specific tools between baseline and day 42, the French translation version of the Dermatology Life Quality Index (DLQI) and the VQ-Dermato (a French-language scoring instrument). The intent-to-treat population comprised 137 patients [desloratadine (n = 65) or placebo (n = 72)]. Desloratadine treatment was associated with significantly greater improvements from baseline to day 42 compared with placebo in DLQI overall score (-6 vs. -2.2 points; P < 0.002) and VQ-Dermato score (18.5 vs. 29.1 points; P = 0.009). Mean scores for sleep disruption and disruption of daily activities were significantly lower in the desloratadine group than in the placebo group from day 1 to the end of the study. Desloratadine 5 mg/day was associated with significant improvements in two separate de...Continue Reading

Associated Clinical Trials

References

Jun 29, 1995·The New England Journal of Medicine·M W Greaves
Apr 21, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J RingR Engst
Aug 12, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y G Yap, A J Camm
Dec 11, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·J J GrobJ J Bonerandi
Aug 9, 2002·European Journal of Pharmacology·John C AnthesRobert E Egan
Mar 29, 2003·Journal of the American Academy of Dermatology·Eugene MonroeUNKNOWN Desloratadine Uritcaria Study Group
Aug 27, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Richard D Lennox, Michael J Leahy
Sep 7, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E NettisA Ferrannini
Jan 27, 2006·Allergy·T ZuberbierB Wedi
Feb 8, 2006·Clinical Reviews in Allergy & Immunology·Jean-Jacques Grob, Caroline Gaudy-Marqueste

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