Quality of life in heart failure with preserved ejection fraction: importance of obesity, functional capacity, and physical inactivity.

European Journal of Heart Failure
Yogesh N V ReddyBarry A Borlaug

Abstract

Patient-reported quality of life (QOL) is a highly prognostic and clinically relevant endpoint in patients with heart failure (HF) with preserved ejection fraction (HFpEF). The relationships between QOL and different markers of HF severity remain unclear, particularly as they relate to functional capacity and directly measured activity levels. We hypothesized that QOL would demonstrate a stronger relationship with measures of exercise capacity and adiposity compared to other disease measures. This is a secondary analysis of the National Heart, Lung, and Blood Institute-sponsored RELAX, NEAT-HFpEF and INDIE-HFpEF trials to determine the relationships between QOL (assessed by the Kansas City Cardiomyopathy Questionnaire and Minnesota Living with Heart Failure Questionnaire) and different domains reflecting HF severity, including maximal aerobic capacity (peak oxygen consumption), submaximal exercise capacity (6-min walk distance), volume of daily activity (accelerometry), physician-estimated functional class, resting echocardiography, and plasma natriuretic peptide levels. A total of 408 unique patients with chronic HFpEF were split into tertiles of QOL scores defined as QOLworst, QOLintermediate , QOLbest . The QOLworst HFpEF gr...Continue Reading

References

Apr 12, 2000·Journal of the American College of Cardiology·C P GreenJ A Spertus
Nov 7, 2002·JAMA : the Journal of the American Medical Association·Dalane W KitzmanKathryn P Stewart
Dec 26, 2006·European Journal of Heart Failure·Eldrin F LewisUNKNOWN CHARM Investigators
Sep 4, 2010·Journal of the American College of Cardiology·Barry A BorlaugMargaret M Redfield
Jun 30, 2011·European Journal of Heart Failure·Tialda HoekstraTiny Jaarsma
Sep 20, 2012·Circulation. Heart Failure·Margaret M RedfieldUNKNOWN Heart Failure Clinical Research Network
Feb 22, 2013·European Journal of Heart Failure·Muaz M AbudiabBarry A Borlaug
Mar 13, 2013·JAMA : the Journal of the American Medical Association·Margaret M RedfieldUNKNOWN RELAX Trial
Mar 19, 2013·Journal of the American College of Cardiology·Dirk J van VeldhuisenHans L Hillege
Nov 10, 2015·The New England Journal of Medicine·Margaret M RedfieldUNKNOWN NHLBI Heart Failure Clinical Research Network
Jul 9, 2016·Journal of the American College of Cardiology·Daniel DalosDiana Bonderman
Dec 3, 2016·JACC. Heart Failure·Emer JoyceUNKNOWN Heart Failure Apprentice Network
Jan 12, 2017·The New England Journal of Medicine·Ethan Basch
May 23, 2018·European Heart Journal·Masaru ObokataBarry A Borlaug
Nov 7, 2018·JAMA : the Journal of the American Medical Association·Barry A BorlaugUNKNOWN National Heart, Lung, and Blood Institute Heart Failure Clinical Research Network
Dec 20, 2018·Circulation·Jasper TrompCarolyn S P Lam
Jul 16, 2019·JACC. Heart Failure·Yogesh N V ReddyBarry A Borlaug
Jul 16, 2019·JACC. Heart Failure·Alvin ChandraUNKNOWN PARAGON-HF Investigators

❮ Previous
Next ❯

Citations

Mar 11, 2020·European Journal of Heart Failure·Muhammad Shahzeb KhanStephen J Greene
Apr 2, 2020·Nature Reviews. Cardiology·Barry A Borlaug
Jan 6, 2021·Journal of the American Geriatrics Society·Melissa C CaugheyAmbarish Pandey
Oct 30, 2020·Frontiers in Endocrinology·Danielle L KirkmanSalvatore Carbone
Nov 15, 2020·Nature Reviews. Cardiology·Arnold C T NgJeroen J Bax
May 31, 2021·Heart Failure Clinics·Dong-Hyuk Cho, Byung-Su Yoo
May 31, 2021·Heart Failure Clinics·Efstratios KoutroumpakisAnita Deswal
May 31, 2021·Heart Failure Clinics·Hidemi SorimachiBarry A Borlaug
May 16, 2021·Journal of Cardiac Failure·Michael F CosianoStephen J Greene
Jun 20, 2021·European Journal of Heart Failure·Matteo PagnesiMarco Metra
Jun 29, 2021·European Journal of Heart Failure·Daniela TomasoniMarco Metra
Aug 12, 2021·Journal of Cellular and Molecular Medicine·Yueqiu ChenZhenya Shen
Oct 30, 2021·European Journal of Heart Failure·Daniela TomasoniMarco Metra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.