Abstract
Spinocerebellar ataxia type 10 (SCA10) is characterized by gait ataxia, dysarthria, nystagmus, epilepsy, reduced cognitive ability and depression, which lead to functional loss and behavioral changes. These signs gradually evolve and may interfere with the physical, emotional, and social aspects of quality of life (QoL). To assess the self-perception of quality of life and its association with disease duration, severity of ataxia, balance and functional independence. This study focused on the disease duration, ataxia severity (SARA), balance (Berg Balance Scale), functionality (FIM, Lawton IADL) and QoL (SF-36 v.2) of 15 individuals with SCA10. The population sample consisted of eight females and seven males, with a mean age of 43.8 (± 8.2) years, mean age of symptom onset of 33.1 (± 8.9) years and mean disease duration of 9.8 (± 11.2) years. The mean Berg Balance Scale score was 47.2 (± 12), mean SARA score (n = 14) 11.5 (± 7.3), mean Lawton IADL score 20.4 (± 1.8) and mean FIM score 120.3 (± 5.4). Individuals with SCA10 had a greater impairment of QoL in the "role-physical" domain (p = 0.04). The longer the disease duration (p = 0.02), risk of falling (p = 0.04), severity of ataxia (p = 0.00) and functional dependence in acti...Continue Reading
References
Nov 1, 1995·Social Science & Medicine
Jun 1, 1997·Injury Prevention : Journal of the International Society for Child and Adolescent Injury Prevention·C E CassadyM L Goggin
Apr 22, 2004·Lancet Neurology·Ludger SchölsOlaf Riess
Aug 31, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S T MiyamotoJ Natour
Oct 24, 2007·Journal of the Neurological Sciences·Ichiro YabeHidenao Sasaki
Feb 4, 2010·Current Medical Research and Opinion·Philippe Nuss, Cedric Tessier
Aug 30, 1946·Public Health Reports
May 3, 2011·Parkinsonism & Related Disorders·Hélio A G TeiveTetsuo Ashizawa
Oct 28, 2011·Ciência & saúde coletiva·Graziela Macedo Bastos LandeiroElizabete Regina de Araújo Oliveira
Jun 6, 2012·Clinics·Hélio A G TeiveTetsuo Ashizawa
Aug 15, 2013·The Cerebellum·Raphael Machado de CastilhosUNKNOWN Rede Neurogenetica
Aug 29, 2013·Arquivos de neuro-psiquiatria·Carolina Yuri P AizawaOrlando Graziani Povoas Barsottini
Mar 1, 2014·Brain : a Journal of Neurology·Tracey D GravesUNKNOWN CINCH Investigators
Jun 5, 2014·Revista brasileira de epidemiologia = Brazilian journal of epidemiology·Josue LaguardiaMiguel Murat Vasconcellos
Apr 5, 2015·Journal of the Neurological Sciences·Geneieve TaiMartin B Delatycki
Sep 1, 2016·International Psychogeriatrics·G PusswaldJ Lehrner
Aug 17, 2017·Arquivos de neuro-psiquiatria·Raissa Carla MoreiraHélio A G Teive
Oct 1, 2016·Dementia & Neuropsychologia·Adriana Moro, Hélio Afonso Ghizoni Teive
Dec 14, 2017·Arquivos de neuro-psiquiatria·Thiago R Padilha AmaranteMarise Bueno Zonta