Quality of life in long-term botulinum toxin treatment of cervical dystonia: Results of a cross sectional study

Parkinsonism & Related Disorders
Marek MollHarald Hefter

Abstract

Patients' rating of the effectiveness of and quality of life after long-term botulinum toxin (BoNT) injection therapy up to 22 years and treating physician's rating of the therapy effect in patients with idiopathic cervical dystonia (CD) are analysed in a large monocentric cross-sectional study. Patients (n = 221) who received uninterrupted, long-term treatment for CD (≥10 BoNT injection cycles) in a BoNT outpatient clinic underwent detailed clinical investigation, Tsui scoring, rated post-treatment CD severity as a percentage of CD severity prior to BoNT injection (patient's subjective scoring of the treatment effect (PSSTE)), and completed the CDQ-24 quality of life (QoL) questionnaire. Correlations between demographics, treatment-related data and QoL were analysed by linear regression, analysis of variance and pairwise single comparisons. Treating physicians and patients rated mean ongoing treatment effect as >50%. There was high variability of duration of treatment, PSSTE, Tsui score and CDQ-24 across all patients. PSSTE was significantly correlated with Tsui score (p < .001) and all CDQ-24 subscores (p < .003). Tsui score and CDQ-24 were significantly correlated (p < .001), but the correlation was lower than between PSSTE ...Continue Reading

Citations

Mar 5, 2021·Neuroscience and Biobehavioral Reviews·Alex Medina EscobarDavide Martino
Sep 21, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Grace A BaileyKathryn J Peall

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