Quality of life indices may be predictive of placebo and medication response to treatment for allergic rhinitis

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
A K EllisJ H Day

Abstract

Quality of life (QOL) is known to be an important clinical endpoint in determining medication efficacy; however, the predictive value of QOL indices for response to medication or placebo has not been tested. To determine whether a correlation between measures of QOL and response to medication/placebo exists in an evaluation of budesonide for allergic rhinitis. Two hundred nine participants completed the 36-item short-form health QOL survey at screening for entry into a study examining the onset of action of budesonide in an allergen challenge system. During the treatment phase, symptom assessments were recorded hourly after dosing of double-blind medication. Participants were determined to be responders or nonresponders to study medication. A responder was defined as a participant who rated medication effectiveness as fair to excellent with regard to symptom relief, for three consecutive hourly assessments during the study day or one whose total symptom score decreased by > or =25% for three consecutive hourly assessments. Baseline QOL scores were compared between responders and nonresponders. Differences were noted among responders and nonresponders on the basis of whether budesonide or placebo was received. Ratings of general...Continue Reading

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Citations

Mar 5, 2005·The Journal of Allergy and Clinical Immunology·Elizabeth F JuniperPeter H Howarth
Feb 28, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·James H DayMaureen P Briscoe
Oct 16, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Anne K EllisLisa M Steacy
Jul 2, 2015·Current Allergy and Asthma Reports·Michelle L NorthAnne K Ellis
Feb 6, 2015·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Anne K EllisTerry Jb Walker
Mar 24, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K P LeongH H Chng

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