Quality of life of breast cancer patients receiving high-dose-intensity chemotherapy: impact of length of cycles

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
D GenreP Viens

Abstract

This study was designed to measure treatment side-effects and quality of life (QL) of 47 nonmetastatic breast cancer patients subjected to a dose-intensity increase while receiving a sequential high dose chemotherapy (doxorubicin+cyclophosphamide - 4 cycles). The dose-intensity increase was obtained by shortening the length of cycles from 21 to 14 days. Treatment side-effects were self-assessed in terms of frequency and associated distress in cycles 1 and 3 by using a specific side-effect self-report questionnaire (19 items). Multidimensional QL measurement was performed at inclusion and before the start of cycles 2 and 4, by using the EORTC QLQ-C30. Pain was evaluated by patients on a visual analogue scale at the same times as QL evaluation. Patients' self-ratings indicated that the total number of symptoms, the number of symptoms rated by patients as quite or very distressing, and symptom frequency were comparable whatever the length of cycle. Overall, although underestimating most patients' symptoms, physicians' reports provided similar results. However, analysis of multidimensional QL showed that, in comparison to standard administration of 4 cycles of 21 days, there was a more significant deterioration of the QLQ-C30 globa...Continue Reading

Citations

Aug 8, 2007·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·K BudischewskiSt Mose
Jul 11, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Claude SportèsRonald E Gress
Sep 2, 2008·Journal of Experimental & Clinical Cancer Research : CR·Ali Montazeri
Aug 27, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Matti AaproVicente Valero
Jan 25, 2014·Cancer Nursing·Susanne Hellerstedt-BörjessonCecilia Arving

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