Quality of life of children and adolescents with chronic kidney disease: a cross-sectional study

Archives of Disease in Childhood
Anna FrancisGermaine Wong

Abstract

The aim was to compare quality of life (QoL) among children and adolescents with different stages of chronic kidney disease (CKD) and determine factors associated with changes in QoL. Cross-sectional. The Kids with CKD study involved five of eight paediatric nephrology units in Australia and New Zealand. There were 375 children and adolescents (aged 6-18 years) with CKD, on dialysis or transplanted, recruited between 2013 and 2016. Overall and domain-specific QoL were measured using the Health Utilities Index 3 score, with a scale from -0.36 (worse than dead) to 1 (perfect health). QoL scores were compared between CKD stages using the Mann-Whitney U test. Factors associated with changes in QoL were assessed using multivariable linear and ordinal logistic regression. QoL for those with CKD stages 1-2 (n=106, median 0.88, IQR 0.63-0.96) was higher than those on dialysis (n=43, median 0.67, IQR 0.39-0.91, p<0.001), and similar to those with kidney transplants (n=135, median 0.83, IQR 0.59-0.97, p=0.4) or CKD stages 3-5 (n=91, 0.85, IQR 0.60-0.98). Reductions were most frequent in the domains of cognition (50%), pain (42%) and emotion (40%). The risk factors associated with decrements in overall QoL were being on dialysis (decremen...Continue Reading

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Citations

Dec 24, 2018·Seminars in Dialysis·Rute AguiarBengt Lindholm
Aug 2, 2019·Journal of the American Society of Nephrology : JASN·Nicholas G Larkins, Jonathan C Craig
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Jul 12, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hannah Jacob, Matko Marlais
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Sep 8, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Melanie K AldridgeSteven J McTaggart
Jun 28, 2020·Pediatrics·Olga CharnayaJohn D Lantos

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