Quality of life of irradiated brain tumor survivors treated with donepezil or placebo: Results of the WFU CCOP research base protocol 91105

Neuro-oncology Practice
Michelle NaughtonStephen R Rapp

Abstract

The health-related quality of life (HRQL) and fatigue of brain cancer survivors treated with donepezil or placebo for cognitive symptoms after radiation therapy were examined. One hundred ninety-eight patients who completed >30 Gy fractionated whole or partial brain irradiation at least 6 months prior to enrollment were randomized to either placebo or donepezil (5 mg for 6 weeks followed by 10 mg for 18 weeks) in a phase 3 trial. A neurocognitive battery, the Functional Assessment of Cancer Therapy-Brain (FACT-Br) and the Functional Assessment of Chronic Illness Therapy (FACIT)-fatigue, was administered at baseline, 12 weeks, and 24 weeks. At 12 weeks, donepezil resulted in improvements in only emotional functioning (P = .04), with no significant effects at week 24. Associations by level of baseline cognitive symptoms (above or below the median score of the baseline FACT-Br "additional concerns/brain" subscale), indicated that participants with more baseline symptoms who received donepezil versus placebo, showed improvements in social (P = .02) and emotional well-being (P = .038), other concerns/brain (P = .003) and the FACT-Br total score (P = .004) at 12 weeks, but not 24 weeks. However, participants with fewer baseline sympt...Continue Reading

References

Sep 15, 2001·Journal of General Internal Medicine·K KroenkeJ B Williams
Aug 6, 2002·Nature Medicine·Michelle L MonjeTheo D Palmer
Aug 28, 2003·Lancet Neurology·Elio ScarpiniHoward Feldman
Jan 13, 2004·International Journal of Geriatric Psychiatry·Iracema LeroiLaura Marsh
May 4, 2004·The Lancet Oncology·Alessandro MinisiniLaura Biganzoli
Aug 21, 2004·Clinical Neuropharmacology·Roberto CeravoloLuigi Murri
Jul 16, 2005·Psychopharmacology·Georg GrönManfred Spitzer
Sep 6, 2005·European Psychiatry : the Journal of the Association of European Psychiatrists·Arja MainioPirkko Räsänen
Sep 16, 2005·Journal of Neuro-oncology·Paul D BrownJan C Buckner
Mar 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edward G ShawStephen R Rapp
May 20, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Margareta GustafssonGerd Ahlström
Sep 9, 2006·European Archives of Psychiatry and Clinical Neuroscience·Arja MainioPirkko Räsänen
Mar 31, 2007·Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing·Sherry W FoxElana Farace
Aug 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eduardo BrueraJ Lynn Palmer
May 8, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Elizabeth A KvaleL B Nabors
Apr 23, 2011·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Mariana R GazzottiMilena Vidotto
Mar 9, 2012·The New England Journal of Medicine·Robert HowardPatrick Phillips
Aug 30, 2012·American Journal of Alzheimer's Disease and Other Dementias·Stephen SallowayJoan Mackell
Apr 16, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Barbara L AndersenUNKNOWN American Society of Clinical Oncology
Jul 30, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeanne S MandelblattTim Ahles
Nov 2, 2014·Journal of the National Comprehensive Cancer Network : JNCCN·Crystal S DenlingerDeborah A Freedman-Cass
Apr 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen R RappEdward G Shaw
Jan 8, 2016·Journal of Neuro-oncology·Denise D CorreaLisa M DeAngelis

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