Quality of life on imatinib

Seminars in Hematology
Elizabeth A Hahn, G Alastair Glendenning

Abstract

Imatinib (Gleevec), a highly effective specific tyrosine kinase inhibitor, demonstrates a better side effect profile than interferon-alpha (IFN), which impairs patients' quality of life (QoL). This phase III international study evaluated QoL outcomes in 1,106 newly diagnosed patients with chronic-phase chronic myeloid leukemia (CML) who were randomized to receive either imatinib 400 mg daily or IFN up to 5 MU/m(2)/d with cytarabine (Ara-C) 20 mg/m(2)/d added for 10 days every month (IFN + LDAC). Crossover to the other treatment arm was permitted due to a lack of efficacy or treatment intolerance. QoL was assessed with the Functional Assessment of Cancer Therapy-Biologic Response Modifiers (FACT-BRM) at baseline, monthly for 6 months and then at months 9, 12, and 18. The Trial Outcome Index (TOI; a composite endpoint of physical/functional/treatment-specific subscales) was the primary endpoint. Secondary endpoints measured were social/family well-being (SFWB) and emotional well-being (EWB). QoL was analyzed for the first 18 months of treatment using mixed effects growth curve models. The primary analyses were intention-to-treat (ITT); secondary analyses incorporated crossover as a time-dependent covariate. A total of 1,049 patie...Continue Reading

References

Mar 24, 1994·The New England Journal of Medicine·UNKNOWN Italian Cooperative Study Group on Chronic Myeloid LeukemiaMauro Fiacchini
Jun 1, 1996·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·A E BonomiR Zittoun
Apr 5, 2001·The New England Journal of Medicine·B J DrukerC L Sawyers
Feb 28, 2002·Blood·Michele BaccaraniUNKNOWN Italian Cooperative Study Group on Myeloid Leukemia
Mar 1, 2002·The New England Journal of Medicine·Hagop KantarjianUNKNOWN International STI571 CML Study Group
Mar 15, 2003·The New England Journal of Medicine·Stephen G O'BrienUNKNOWN IRIS Investigators
May 31, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth A HahnUNKNOWN IRIS Investigators
Apr 3, 2004·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·J BacikD Cella

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Citations

May 10, 2006·Nature Clinical Practice. Oncology·Julia D WulfkuhleEmanuel F Petricoin
Feb 6, 2007·Psycho-oncology·Bert VoermanJozien Bensing

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