Quality of life outcomes in transcatheter aortic valve replacement patients requiring pacemaker implantation

Journal of Arrhythmia
Aishwarya BhardwajVijay Iyer

Abstract

Permanent pacemaker implantation is the most common complication after Transcatheter aortic valve replacement (TAVR) and is associated with worse outcomes and mortality. However, its impact on quality-of-life (QoL) outcomes remains unknown. We included 383 consecutive patients undergoing TAVR from January 2012 to 2016 who completed a baseline Kansas City Cardiomyopathy Questionnaire (KCCQ-12) health survey. The clinical, laboratory, angiographic, QoL, mortality, and occurrence of poor outcomes (KCCQ-12 score < 45 or KCCQ decrease of ≥10 points) were obtained. The mean age was 83 ± 8 years, 51% were men, and majority were Caucasians (n = 364, 95%). Permanent pacemaker (PPM) was implanted in 11.5% of patients post-TAVR. PPM patients were more likely to have prior conduction disease including RBBB (25% vs 12%, P = .02) and PQ interval >250 ms (11% vs 5%, P = .07). One-month median KCCQ-12 scores were significantly lower among PPM patients (84.7 vs 68.8, P = .04), but did not differ significantly at 1-year (86.5 vs 90.6, P = .5) post-TAVR. Occurrence of poor outcomes did not differ significantly among those with or without PPM at 1 month (11% vs 7%, P = .39) and 1 year (13% vs 9%, P = .45), respectively. However, patients with poor...Continue Reading

References

Jan 1, 1984·The American Journal of Cardiology·Z LababidiJ T Walls
Oct 1, 1993·Journal of the American College of Cardiology·G H Guyatt
Apr 12, 2000·Journal of the American College of Cardiology·C P GreenJ A Spertus
Oct 8, 2005·American Heart Journal·John SpertusUNKNOWN Cardiovascular Outcomes Research Consortium
Jan 9, 2008·The Journal of Thoracic and Cardiovascular Surgery·Todd M DeweyMichael J Mack
Jan 14, 2009·BMJ : British Medical Journal·Despina G Contopoulos-IoannidisJohn P A Ioannidis
Oct 22, 2010·The New England Journal of Medicine·Martin B LeonUNKNOWN PARTNER Trial Investigators
Apr 26, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Kathrin AmonnChristoph Huber
Jul 10, 2012·The American Journal of Cardiology·Ana LaynezRon Waksman
Aug 25, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Maurizio TaramassoFrancesco Maisano
Sep 11, 2012·The Annals of Thoracic Surgery·Ruben L J OsnabruggeM G Myriam Hunink
Apr 26, 2013·The New England Journal of Medicine·Anne B CurtisUNKNOWN Biventricular versus Right Ventricular Pacing in Heart Failure Patients with Atrioventricular Block (BLOCK HF) Trial Investi
Apr 15, 2014·Annals of Internal Medicine·Caroline A KimDae Hyun Kim
May 6, 2015·Pacing and Clinical Electrophysiology : PACE·Abhishek MaanMoussa Mansour
Aug 27, 2015·Circulation. Cardiovascular Quality and Outcomes·John A Spertus, Philip G Jones
Apr 5, 2016·The New England Journal of Medicine·Martin B LeonUNKNOWN PARTNER 2 Investigators
Dec 23, 2016·JACC. Cardiovascular Interventions·Rüdiger LangeUNKNOWN GARY Executive Board

❮ Previous
Next ❯

Citations

Apr 11, 2019·Herzschrittmachertherapie & Elektrophysiologie·Salma HajKhederChristian Butter
Dec 7, 2019·Scandinavian Cardiovascular Journal : SCJ·Sindri A ViktorssonTomas Gudbjartsson
Mar 30, 2021·Journal of the American Heart Association·Justine M RavauxRoberto Lorusso

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation

Software Mentioned

STATA

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.