Quality of Life Perception, Cognitive Function, and Psychological Status in a Real-world Population of Glioblastoma Patients Treated With Radiotherapy and Temozolomide: A Single-center Prospective Study

American Journal of Clinical Oncology
Giuseppe LombardiVittorina Zagonel

Abstract

Health-related quality of life (HRQoL), cognitive function, and psychological status represent an important focus during the treatment of glioblastoma patients. Nevertheless, few randomized, prospective clinical trials have analyzed these factors, and very little is known in the real-clinical world. We evaluated these characteristics in glioblastoma patients treated with standard first-line therapy outside clinical trials. In total, 111 newly, histologically diagnosed glioblastoma patients treated at our oncology center with radiotherapy and temozolomide were prospectively enrolled. No patient was enrolled in an experimental clinical trial. We assessed HRQoL, cognitive function, and psychological status before starting treatment, at the end of radiotherapy, and every 3 months until 9 months after the end of radiotherapy using EORTC QLQ-C30, BN20, MMSE, and HADS questionnaires. Global health status, physical, cognitive, and social functioning remained unchanged throughout the study period. A statistically significant change was found in emotional functioning as well as a clinically meaningful amelioration in role functioning between the baseline assessment and 9 months after radiotherapy. Patients older than 65 years reported gr...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Aug 1, 1984·Journal of Clinical Neuropsychology·J Hom, R M Reitan
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Jan 24, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D OsobaJ Pater
Feb 19, 2000·International Journal of Cancer. Supplement = Journal International Du Cancer. Supplement·D Osoba
Sep 7, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D OsobaM D Prados
Feb 13, 2001·BMJ : British Medical Journal·J A Sterne, G Davey Smith
Oct 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M KleinN K Aaronson
Jan 31, 2002·Journal of Neuro-oncology·M P RogersP M Black
Feb 28, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·J SaloJ Koivukangas
Sep 3, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F Efficace, A Bottomley
Feb 28, 2003·International Journal of Radiation Oncology, Biology, Physics·C A HahnE C Halperin
Jun 28, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul D BrownEdward G Shaw
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Dec 3, 2005·The Lancet Oncology·Martin J B TaphoornUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Feb 26, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Martin J B TaphoornUNKNOWN EORTC Quality of Life Group, and Brain Cancer, NCIC and Radiotherapy Groups
Mar 17, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick Y WenSusan M Chang
May 29, 2010·The Oncologist·Martin J B TaphoornAndrew Bottomley
Sep 8, 2010·The New England Journal of Medicine·Jennifer S TemelThomas J Lynch
Dec 14, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Cagdas YavasFadil Akyol
Nov 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Valen E Johnson
Feb 21, 2014·The New England Journal of Medicine·Mark R GilbertMinesh P Mehta
Feb 21, 2014·The New England Journal of Medicine·Olivier L ChinotTimothy Cloughesy
Mar 5, 2014·Journal of Neurology·Anna Rita GiovagnoliAmerigo Boiardi
May 28, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martin J B TaphoornOlivier L Chinot
Oct 3, 2015·Journal of Neurosurgery·Lisa Millgård SagbergAsgeir S Jakola
Mar 8, 2016·Handbook of Clinical Neurology·Hans-Georg WirschingMichael Weller
Mar 26, 2016·Journal of Neurosurgery·Christina DrewesOle Solheim
Dec 31, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Betty R FerrellThomas J Smith
Mar 16, 2017·The New England Journal of Medicine·James R PerryUNKNOWN Trial Investigators

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