Quality of oral anticoagulation with vitamin K antagonists in 'real-world' patients with atrial fibrillation: a report from the prospective multicentre FANTASIIA registry

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
María Asunción Esteve-PastorFANTASIIA Investigators

Abstract

The efficacy and safety of oral anticoagulation (OAC) using the vitamin K antagonists (VKA) are closely associated with the quality of anticoagulation, reflected by time in therapeutic range (TTR). The SAMe-TT2R2 is a risk score developed to predict the quality of anticoagulation control among VKA users. To analyse the quality of anticoagulation and its clinical determinants based on different methods in a prospective cohort of atrial fibrillation patients on VKA treatment participating in the multicentre Spanish observational registry FANTASIIA. Estimated TTR was calculated from Rosendaal, direct method, international normalized ratio variability, and NICE criteria. Time in therapeutic range values were compared for those patients with a SAMe-TT2R2 score 0-2 and >2. One thousand four hundred and seventy patients were analysed (56.4% male, mean age 74.1 ± 9.5 years). Mean TTR was 61.5 ± 25.1 with Rosendaal and 64.7 ± 24.2 with direct method. There was a high correlation between both methods (ρ = 0.805). The prevalence of poor anticoagulation control was 55%. Diabetes mellitus [odds ratio (OR) 1.38; P = 0.008], peripheral artery disease (PAD, OR 1.62; P = 0.048), and HAS-BLED (OR 1.13; P = 0.022) were independently associated wi...Continue Reading

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Citations

Nov 26, 2019·Medical Care·Aníbal García-SempereGabriel Sanfélix-Gimeno
May 30, 2020·Journal of Comparative Effectiveness Research·Vivencio BarriosUNKNOWN RE-SONANCE investigator’s group
Aug 4, 2020·International Journal of Clinical Practice·José Miguel Rivera-CaravacaFrancisco Marín
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Nov 23, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Carlos Escobar, A John Camm
Jan 26, 2021·Expert Opinion on Pharmacotherapy·Agnieszka KotalczykGregory Y H Lip
Dec 23, 2020·Journal of Cardiovascular Pharmacology·Alberto CorderoJose R González-Juanatey
May 12, 2021·British Journal of Clinical Pharmacology·Catiane Costa VianaMaria Auxiliadora Parreiras Martins
May 18, 2021·Journal of Cardiology Cases·Yusuke AkazawaOsamu Yamaguchi
Jun 12, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·José Miguel Rivera-CaravacaFrancisco Marín
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Jul 26, 2021·Experimental Gerontology·Marco ProiettiUNKNOWN FANTASIIA Study Investigators
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