Quality of performance of assays for serum growth hormone in the United Kingdom (UK): evidence from the UK external quality assessment scheme, 1980-1987

Clinica Chimica Acta; International Journal of Clinical Chemistry
J SethW M Hunter

Abstract

The performance of laboratories in the UK External Quality Assessment Scheme for growth hormone (GH) during the years 1980 to 1987 is reviewed. The number of participating laboratories has increased steadily and is at present 67; about one half use immunoradiometric assay (IRMA) kits and the use of such kits is increasing at the expense of 'in-house' radioimmunoassays (RIAs). The consensus mean, which is used as the target value for assessing performance, has remained accurate and reproducible against this changing background. The between-laboratory geometric coefficient of variation has remained at about 18% during the period reviewed, revealing unsatisfactory between-laboratory agreement. This is in part due to poor within-laboratory performance in a small proportion of laboratories but it is also due to the negative bias of some IRMA kits. Most IRMA kits do appear, however, to provide marginally better within-laboratory precision than RIA, and are less vulnerable to non-specific interference. The laboratory interpretation of results was assessed from time to time, and was generally satisfactorily performed. In an attempt to identify the causes of poor performance, a detailed survey of assay methods and laboratory practice ha...Continue Reading

References

May 31, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·J Seth, I Hanning
Jun 1, 1985·The Journal of Clinical Endocrinology and Metabolism·G BaumannK Amburn
Sep 1, 1981·Journal of Clinical Pathology·T P Whitehead, F P Woodford

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Citations

May 31, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·J Seth, I Hanning
Oct 1, 1994·Clinical Biochemistry·F J Bamforth
Jan 1, 1990·Acta Paediatrica Scandinavica. Supplement·M L GranadaL Audí
Feb 4, 1989·BMJ : British Medical Journal·P M BroughtonR Cramb

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