Quality Saving Mechanisms of Mitochondria during Aging in a Fully Time-Dependent Computational Biophysical Model

PloS One
Daniel MellemMichael Rübhausen

Abstract

Mitochondria are essential for the energy production of eukaryotic cells. During aging mitochondria run through various processes which change their quality in terms of activity, health and metabolic supply. In recent years, many of these processes such as fission and fusion of mitochondria, mitophagy, mitochondrial biogenesis and energy consumption have been subject of research. Based on numerous experimental insights, it was possible to qualify mitochondrial behaviour in computational simulations. Here, we present a new biophysical model based on the approach of Figge et al. in 2012. We introduce exponential decay and growth laws for each mitochondrial process to derive its time-dependent probability during the aging of cells. All mitochondrial processes of the original model are mathematically and biophysically redefined and additional processes are implemented: Mitochondrial fission and fusion is separated into a metabolic outer-membrane part and a protein-related inner-membrane part, a quality-dependent threshold for mitophagy and mitochondrial biogenesis is introduced and processes for activity-dependent internal oxidative stress as well as mitochondrial repair mechanisms are newly included. Our findings reveal a decrease...Continue Reading

References

Jan 1, 1980·Experimental Gerontology·J MiquelJ E Johnson
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·F M Yakes, B Van Houten
Sep 27, 2002·Experimental Biology and Medicine·Yau-Huei Wei, Hsin-Chen Lee
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Stefan H I KappeVictor Nussenzweig
Mar 1, 2005·Cell·Robert S BalabanToren Finkel
Jul 30, 2005·Mitochondrion·Nicolai Balle LarsenLene Juel Rasmussen
May 4, 2007·Archives of Biochemistry and Biophysics·Insil KimJohn J Lemasters
Jul 20, 2007·Biological Trace Element Research·Venkatesh Iyengar
Jul 27, 2007·Alternatives to Laboratory Animals : ATLA·Zuzana CervinkováZdenek Drahota
Apr 2, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Terry D OberleyKevin C Kregel
Mar 7, 2009·Nucleic Acids Research·Inna ShokolenkoMikhail F Alexeyev
May 6, 2009·Biophysical Journal·Pradeep K MouliOrian S Shirihai
Jun 11, 2010·Essays in Biochemistry·François R Jornayvaz, Gerald I Shulman
Oct 14, 2010·Journal of Cell Science·Arnold Y SeoChristiaan Leeuwenburgh
Dec 7, 2010·Antioxidants & Redox Signaling·Gilad Twig, Orian S Shirihai
Jul 5, 2012·PLoS Computational Biology·Marc Thilo FiggeHeinz D Osiewacz
Sep 1, 2012·Science·Richard J Youle, Alexander M van der Bliek
Mar 13, 2013·Cell Biochemistry and Biophysics·Nikolaus Berndt, Hermann-Georg Holzhütter
May 3, 2013·Cold Spring Harbor Perspectives in Biology·Mikhail AlexeyevSusan LeDoux
Jun 5, 2013·Cold Spring Harbor Perspectives in Biology·Alexander M van der BliekSumihiro Kawajiri
Jun 5, 2013·Cold Spring Harbor Perspectives in Biology·Thomas L Schwarz
Jul 23, 2013·PLoS Computational Biology·Pinkesh K PatelKerwyn Casey Huang
Jul 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Stéphane G RollandBarbara Conradt
Feb 4, 2014·Experimental Gerontology·Konstantinos Palikaras, Nektarios Tavernarakis
May 28, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Karin B BuschJohannes N Spelbrink

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Citations

Mar 31, 2017·PLoS Biology·Roland G Roberts
Sep 12, 2018·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Daniel MellemMichael Rübhausen
Jun 24, 2017·PloS One·Daniel MellemFrank Fischer

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