Quality specification in haematology: the automated blood cell count

Clinica Chimica Acta; International Journal of Clinical Chemistry
Mauro Buttarello

Abstract

Quality specifications for automated blood cell counts include topics that go beyond the traditional analytic stage (imprecision, inaccuracy, quality control) and extend to pre- and post-analytic phases. In this review pre-analytic aspects concerning the choice of anticoagulants, maximum conservation times and differences between storage at room temperature or at 4 degrees C are considered. For the analytic phase, goals for imprecision and bias obtained with various approaches (ratio to biologic variation, state of the art, specific clinical situations) are evaluated. For the post-analytic phase, medical review criteria (algorithm, decision limit and delta check) and the structure of the report (general part and comments), which constitutes the formal act through which a laboratory communicates with clinicians, are considered. K2EDTA is considered the anticoagulant of choice for automated cell counts. Regarding storage, specimens should be analyzed as soon as possible. Storage at 4 degrees C may stabilize specimens from 24 to 72 h when complete blood count (CBC) and differential leucocyte count (DLC) is performed. For precision, analytical goals based on the state of the art are acceptable while for bias this is satisfactory on...Continue Reading

References

Jan 1, 1991·Clinical and Laboratory Haematology·W GoossensR L Verwilghen
Feb 1, 1991·American Journal of Clinical Pathology·B A Warner, D M Reardon
Feb 1, 1985·American Journal of Clinical Pathology·L P SkendzelR Platt
Dec 1, 1996·American Journal of Clinical Pathology·A R JonesE Gottfried
Nov 5, 1999·American Journal of Clinical Pathology·B L WoodD E Sabath
Feb 10, 2000·Scandinavian Journal of Clinical and Laboratory Investigation·S Sandberg, G Thue
Nov 14, 2002·American Journal of Clinical Pathology·Linda M Sandhaus, Pamela Meyer

❮ Previous
Next ❯

Citations

Mar 17, 2007·Scandinavian Journal of Clinical and Laboratory Investigation·B KornblitH Birgens
Sep 4, 2015·International Journal of Laboratory Hematology·H KimY-M Yun
Jun 21, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Mario Plebani
Dec 3, 2008·International Journal of Laboratory Hematology·T Lehto, P Hedberg
Jan 8, 2008·International Journal of Laboratory Hematology·E GrimaldiM De Caterina
Oct 20, 2010·Acta Clinica Belgica·I Van HeckeJ Van Den Bossche
Sep 27, 2006·Clinical and Laboratory Haematology·G LippiG C Guidi
Oct 26, 2012·Cell Biochemistry and Function·C FaggioF Fazio
Jul 25, 2012·International Journal of Laboratory Hematology·E CornetX Troussard
Jan 1, 2014·International Journal of Laboratory Hematology·G Zini, UNKNOWN International Council for Standardization in Haematology (ICSH)
Oct 18, 2014·Internal and Emergency Medicine·Benjamin A von SchweinitzPaul B Allen
May 11, 2016·International Journal of Laboratory Hematology·J Y Vis, A Huisman
Jun 11, 2016·American Journal of Clinical Pathology·Steffen MannußPeter Kohlschein
Oct 7, 2016·Journal of Clinical Laboratory Analysis·Sabrina BuoroGiuseppe Lippi
Jan 21, 2016·Journal of Clinical Pathology·Yaara Ben-YosefAvishay Bransky
Oct 5, 2017·International Journal of Laboratory Hematology·S PipitoneS Buoro
Mar 8, 2018·International Journal of Laboratory Hematology·L R OliveiraD C K Borato
Feb 7, 2018·International Journal of Laboratory Hematology·A MolinaA Merino
Dec 3, 2005·Analytical and Bioanalytical Chemistry·Erwin Schleicher
Jul 25, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Angel MolinaAnna Merino
May 26, 2007·Clinical Chemistry·Paolo Carraro, Mario Plebani
Feb 24, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Sarah BirindelliMauro Panteghini
Apr 14, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Lin-Lin PanCheuk-Kwan Sun
Jul 26, 2018·Environmental Science and Pollution Research International·Mohamed M Abdel-DaimSimona G Bungau
Mar 16, 2017·International Journal of Laboratory Hematology·S BuoroG Lippi
Nov 12, 2020·International Journal of Laboratory Hematology·Matteo VidaliSabrina Buoro
Jun 11, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·E M TanvirP Nicholas Shaw
Jun 29, 2021·Journal of Medical Biochemistry·Ozmen Sevda Unalli, Yesim Ozarda
Sep 11, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Doaa H AssarAyman Atiba

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.